Publications by authors named "Takaya Namiki"

Background: Although vancomycin is commonly used to treat methicillin-resistant coagulase-negative staphylococci (MRCoNS) infections, there are no clear guidelines for the optimal 24 h AUC24/MIC ratio. This study aimed to determine the target AUC24/MIC ratio associated with vancomycin-treated MRCoNS infection outcomes.

Methods: This multicentre retrospective cohort study included adult patients who received vancomycin for ≥5 days for bloodstream infections caused by MRCoNS between January 2018 and December 2023.

View Article and Find Full Text PDF

Background: Although vancomycin is typically employed against methicillin-resistant Staphylococcus aureus (MRSA) infections, the optimal ratio of 24-h area under the concentration-time curve to minimum inhibitory concentration (AUC/MIC) for severe or complicated infections lacks clear guideline recommendations. This study aimed to determine the target AUC/MIC ratio associated with treatment outcomes of infections treated with vancomycin.

Methods: This retrospective multicenter cohort study included adult patients receiving ≥ 5 days of vancomycin for severe/complicated MRSA infections (e.

View Article and Find Full Text PDF
Article Synopsis
  • The study aimed to develop methods for measuring cefmetazole (CMZ) levels and perform a pharmacokinetic/pharmacodynamic analysis for patients with extended-spectrum β-lactamase producing enterobacterales (ESBL-E), focusing on optimal dosing for both hemodialysis (HD) and non-hemodialysis (non-HD) patients.
  • Conducted as a prospective observational study, the research included patients at the Tokyo Bay Urayasu Ichikawa Medical Center between August 2021 and July 2022 who were treated with CMZ and provided written consent.
  • Measurement techniques included high-performance liquid chromatography (HPLC) for total and unbound CMZ concentrations, and the study utilized models and nomograms to
View Article and Find Full Text PDF