Publications by authors named "Takatoshi Kasai"

Ballistocardiogram (BCG) captures minute vibrations generated by heart movements. These vibrations are converted into heart rate variability (HRV) indices, allowing their unobtrusive monitoring over extended periods, while reducing the burden on patients or subjects. In this study, to evaluate the agreement between the HRV indices, we compared the HRV indices estimated from the BCG device with those obtained from the gold standard electrocardiogram (ECG).

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Background And Aims: In patients with heart failure (HF), differences in the association between estimated protein intake (PI) and prognosis in those with and without chronic kidney disease (CKD) remain to be clarified. This study aimed to investigate whether the prognostic effects of the estimated PI differ between patients with HF with and without CKD.

Methods: We included patients who required hospitalisation owing to worsening HF between 2015 and 2019 and assessed the estimated PI based on the adjusted Maroni formula using the body mass index and urinary urea nitrogen level.

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  • Older patients with heart failure (HF) experience a higher risk of developing pneumonia, which contributes to increased mortality rates.
  • A study of 1,266 hospitalized patients aged 65 and older found that those with low muscle strength were significantly more likely to develop pneumonia post-discharge.
  • Low muscle strength was identified as a strong predictor of pneumonia and associated with a fourfold increased risk of death after pneumonia onset.
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Objectives: The Asian Working Group for Sarcopenia in 2019 (AWGS 2019) emphasized muscle mass measurements. In contrast, the Sarcopenia Definitions and Outcomes Consortium (SDOC) prioritizes functional strength and mobility. Therefore, this study aimed to compare the prognostic utility of the SDOC and AWGS 2019 criteria for all-cause mortality in older patients with heart failure.

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  • Sleep apnea is common in patients with heart failure and can worsen their health outcomes; the study examines the effects of tofogliflozin, an SGLT2 inhibitor, on this condition.
  • In the study, tofogliflozin significantly lowered the apnea-hypopnea index (AHI) in patients after 6 months, indicating reduced severity of sleep apnea.
  • Improvements in body weight and water content were seen alongside the reduction in AHI, suggesting a possible link between decreased body water and sleep apnea severity, while cardiorenal functions remained unchanged.
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  • The study explores the prevalence of cachexia, sarcopenia, and malnutrition in older patients with heart failure (HF) using definitions from the Asian Working Group for Cachexia (AWGC) and other criteria, finding that AWGC-defined cachexia was the most common condition.
  • Among the 861 patients analyzed, cachexia was present in 74.1%, while other conditions showed lower prevalence rates.
  • The results indicated that AWGC-defined cachexia was not significantly linked to all-cause mortality in these patients, contrasting with stronger associations found for cachexia according to Evans' criteria, sarcopenia, and malnutrition.
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In this study, we aimed to clarify the effects of breakfast intervention on autonomic nerve function in healthcare workers who skip breakfast. This cross-sectional, interventional study was conducted between January 2020 and December 2021. All participants were full-time healthcare workers who completed a self-administered questionnaire on fatigue and subjective symptoms and underwent noninvasive autonomic nerve function tests.

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  • Older patients (65+) with heart failure (HF) often experience physical frailty and malnutrition, which can worsen each other and lead to poor health outcomes.
  • A study involving 862 hospitalized patients found that those with both frailty and malnutrition had the highest risk of death within a year of discharge compared to those with neither condition.
  • Identifying and addressing both frailty and malnutrition in these patients is essential for improving their overall health and survival rates.
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The clinical ramifications of adaptive servo-ventilation (ASV) therapy have stirred debate within the medical community. Given the potential detrimental effect of elevated expiratory positive airway pressure (EPAP) on cardiac output, we hypothesized that relatively lower EPAP may be recommended for successful ASV therapy. In-hospital patients with congestive heart failure refractory to medical therapy were included in the prospective cohort study of ASV therapy on prognosis in repeatedly hospitalized patients with chronic heart failure: longitudinal observational study of effects on readmission and mortality (SAVIOR-L) study.

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Aims: The 6-min walk test (6MWT) is a widely accepted tool for evaluating exercise tolerance and physical capacity, and the 6-min walk distance (6MWD) is an established prognostic factor in patients with heart failure (HF). However, the prognostic implications of post-6MWT dyspnoea remain unknown. We aimed to investigate the prognostic value of Borg scores after the 6MWT in patients with HF.

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Sleep disordered breathing (SDB) is a common comorbidity in patients with atrial fibrillation (AF). Patients undergoing pulmonary vein isolation (PVI) for AF have a high prevalence of SDB. In previous studies, some patients with AF had Cheyne-Stokes respiration (CSR).

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  • Hypochloremia, defined as low chloride levels in the blood, is linked to higher mortality rates in heart failure (HF) patients and was studied to see if it enhances existing prognostic models.
  • In a study of 2,496 hospitalized HF patients, those with hypochloremia had a significantly higher 1-year mortality rate (12.6% of patients had hypochloremia, with 15.5% deaths observed).
  • Adding hypochloremia to established risk models improved predictive accuracy, suggesting it can provide valuable insights into patient outcomes post-discharge.
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Background: Studies comparing the safety of orexin receptor antagonists and other hypnotic types for older patients with heart failure (HF) remain lacking. This study aimed to compare orexin receptor antagonists (suvorexant) with benzodiazepines or Z-drugs for sleep treatment and investigate the risk of acute HF-related rehospitalisation in older patients with HF.

Methods: This study used a cohort design to analyse data from an administrative claims database from April 2008 to December 2020.

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  • The study evaluated the validity of the AWGS 2019 criteria for diagnosing sarcopenia in heart failure patients and proposed a modified model incorporating the 6-minute walk test (6MWT) for better risk stratification.
  • The modified model identified sarcopenia and severe sarcopenia differently than the original, detecting more cases, and showed a stronger link to 2-year mortality rates.
  • Findings suggest that using the 6MWT enhances the ability to assess risk in patients with heart failure, indicating a need to revise current criteria for timely treatment decisions.
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Background: Weight loss is a poor prognostic factor in patients with chronic heart failure (HF). However, whether the same is true for hospitalized patients with HF is unknown, even though hospitalization is the first opportunity for many patients to be diagnosed with HF. This study aimed to investigate the prognostic value of weight loss in patients hospitalized for HF.

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Aims: In heart failure (HF), inflammation is linked to malnutrition and impaired physical function. In this study, we aimed to assess how novel nutritional-inflammatory markers and lymphocyte-to-C-reactive protein ratio (LCR) and score (LCS) are associated with the nutritional status, physical function, and prognosis of patients with HF.

Methods And Results: This study was a secondary analysis of the FRAGILE-HF study, a prospective observational study conducted across 15 hospitals in Japan.

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Unlabelled: We report a case of severe central sleep apnea incidentally diagnosed during polysomnography for suspected obstructive sleep apnea. Characteristic clinical features included episodic hyperventilation followed by apnea from hypocapnia, which did not follow a Cheyne-Stokes pattern. Combined with the identification of cerebellar and brainstem malformations known as the "molar tooth sign" on a brain magnetic resonance imaging, developmental delay, and motor coordination problems, Joubert syndrome (a congenital disease) was first diagnosed at the age of 50 years.

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Repetitive episodes of apnea and hypopnea during sleep in patients with obstructive sleep apnea (OSA) are known to increase the risk of atherosclerosis. Underlying obesity and related disorders, such as insulin resistance, are indirectly related to the development of atherosclerosis. In addition, OSA is independently associated with insulin resistance; however, data regarding this relationship are scarce in Japanese populations.

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Background: Social factors encompass a broad spectrum of nonmedical factors, including objective (social isolation [SI]) and perceived (loneliness) conditions. Although social factors have attracted considerable research attention, information regarding their impact on patients with heart failure is scarce. We aimed to investigate the prognostic impact of objective SI and loneliness in older patients with heart failure.

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Article Synopsis
  • * Out of 77 participants, a majority successfully performed daily self-monitoring, though younger patients and those with more severe HF symptoms were less consistent.
  • * The findings suggest that self-telemonitoring is practical for older HF patients and may help in early detection of worsening conditions, potentially leading to better management and outcomes.
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Purpose: Female athletes with menstrual abnormalities have poor sleep quality. However, whether female athletes with poor sleep quality based on subjective assessment have distinctive changes in objective measures of sleep in association with menses remains unclear. This study aimed to compare changes in objective sleep measurements during and following menses between collegiate female athletes with and without poor subjective sleep quality.

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