Synopsis of recent research by authors named "Takashi Takezawa"
- Takashi Takezawa's research primarily focuses on the expression and regulation of cytochrome P450 enzymes, particularly CYP3A4, in various biological contexts such as human fetal liver cells and placental tissues.
- Significant findings indicate that lower levels of HNF4α and PGC1α can impair CYP3A4 induction in human fetal liver cells, while PXR is crucial for this process in HepG2 cells.
- Additionally, studies on differentiating embryonic stem cells into hepatocytes underscore the importance of culture conditions on the expression of hepatocyte marker genes and drug metabolism-related enzymes.
