Oncolytic herpes virus induces effective anti-cancer immunity against murine colon cancer.

Unlabelled: BACK GROUND/AIMS: Oncolytic virus therapy is becoming a promising anti-cancer therapy and oncolytic viruses have been shown to elicit anti-cancer immunity. We evaluated the anti-tumor immune responses elicited by the herpes oncolytic virus R3616 compared to a representative chemotherapy drug, 5-FU.

Methodology: R3616 or 5-FU was directly injected into subcutaneous tumors of non-immunized mice.

High therapeutic potential for systemic delivery of a liposome-conjugated herpes simplex virus.

Purpose: Oncolytic viral therapy is a newly developed modality to treat tumors. Many clinical trials worldwide have examined the efficacy of locally injected oncolytic viruses. However, systemic intravascular injections are limited by the humoral immune response, which dramatically decreases the level of infection.

Considerations for intravascular administration of oncolytic herpes virus for the treatment of multiple liver metastases.

Purpose: Oncolytic viral therapy is a newly developed modality for treating tumors. Many clinical trials using oncolytic virus have been performed worldwide, but most of them have used local injection in the tumor. Determination of the effect and safety of intravascular virus injection instead of local injection is necessary for clinical use against multiple liver metastases and systemic metastases.

Effects of tumor selective replication-competent herpes viruses in combination with gemcitabine on pancreatic cancer.

Purpose: Pancreatic cancer still has a poor prognosis, even if aggressive therapy is pursued. Currently, new modalities of oncolytic virus therapy are being tested against this cancer. The combination of one of two representative mutant herpes simplex viruses (R3616: gamma(1)34.

Functional roles of lower-limb joint moments while walking in water.

Objective: To clarify the functional roles of lower-limb joint moments and their contribution to support and propulsion tasks while walking in water compared with that on land.

Design: Sixteen healthy, young subjects walked on land and in water at several different speeds with and without additional loads.

Background: Walking in water is a major rehabilitation therapy for patients with orthopedic disorders.

Effect of the walking speed to the lower limb joint angular displacements, joint moments and ground reaction forces during walking in water.

Purpose: The purpose of this study was to compare the changes in ground reaction forces (GRF), joint angular displacements (JAD), joint moments (JM) and electromyographic (EMG) activities that occur during walking at various speeds in water and on land.

Method: Fifteen healthy adults participated in this study. In the water experiments, the water depth was adjusted so that body weight was reduced by 80%.

Lower limb joint moment during walking in water.

Purpose: Walking in water is a widely used rehabilitation method for patients with orthopedic disorders or arthritis, based on the belief that the reduction of weight in water makes it a safer medium and prevents secondary injuries of the lower-limb joints. To our knowledge, however, no experimental data on lower-limb joint moment during walking in water is available. The aim of this study was to quantify the joint moments of the ankle, knee, and hip during walking in water in comparison with those on land.