Publications by authors named "Takashi Hoshikawa"
Major depressive disorder (MDD) is strongly associated with type 2 diabetes mellitus (T2DM). The kynurenine and serotonin pathways, as well as chronic low-grade inflammation, are being considered potential links between them. MDD associated with T2DM is less responsive to treatment than that without T2DM; however, the underlying mechanism remains unknown.
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- The study investigates the differences in serum metabolomics between patients with major depressive disorder (MDD) who have type 2 diabetes mellitus and those who do not, as well as healthy individuals.
- Serum samples from healthy controls, and patients with MDD with and without diabetes were analyzed using advanced mass spectrometry techniques to identify metabolomic patterns.
- The findings highlight distinct metabolic pathways related to energy conversion, glutamate metabolism, and ketone body synthesis, suggesting that MDD patients with diabetes may exhibit different biochemical profiles compared to those without.
Purpose: We investigated the serum levels of cytokines, including interleukin 1β (IL-β), IL-6, IL-8, IL-10, tumor necrosis factor-alpha (TNF-α), and growth factors, including brain-derived neurotrophic factor, vascular endothelial growth factor, and insulin-like growth factor 1, and their association with major depression in patients with and without type 2 diabetes mellitus. We also investigated the response to antidepressant treatment in both groups.
Patients And Methods: Forty-one patients with major depression were recruited at the University Hospital of Occupational and Environmental Health.