A novel amphiphilic squalene-based compound with open-chain polyethers reduces malignant melanoma metastasis in-vitro and in-vivo.

Squalene (SQ) is a well-known antioxidant and anti-inflammatory agent that provides promising anti-aging and UV-protective roles on human skin. However, its strong hydrophobic nature, accompanied by issues such as poor solubility and limited tissue permeation, has created challenges for scientists to investigate its untapped potential in more complex conditions, including cancer progression. The present study assessed the potent anti-metastatic properties of a newly synthesized amphiphilic ethylene glycol SQ derivative (SQ-diEG) in melanoma, the most fatal skin cancer.

Triethylene Glycol Squalene Improves Hair Regeneration by Maintaining the Inductive Capacity of Human Dermal Papilla Cells and Preventing Premature Aging.

De novo hair follicle (HF) regeneration, achieved through the replenishment of the dermal papilla (DP), acknowledged as the principal orchestrator of the hair growth cycle, is emerging as a prospective therapeutic intervention for alopecia. Nonetheless, multiple attempts have shown that these cells lose key inductive properties when cultured in a two-dimensional (2D) monolayer, leading to precocious senescence engendered by oxidative stress and inflammatory processes. Consequently, the three-dimensional (3D) spheroid technique is presently widely employed for DP cell culture.

A comparative transcriptomics analysis reveals ethylene glycol derivatives of squalene ameliorate excessive lipogenesis and inflammatory response in 3T3-L1 preadipocytes.

Squalene (SQ) is a natural compound with anti-inflammatory, anti-cancer, and anti-oxidant effects, but due to its low solubility, its biological properties have been greatly underestimated. This study aims to explore the differences in gene expression patterns of four newly synthesized amphipathic ethylene glycol (EG) derivatives of SQ by whole-genome transcriptomics analysis using DNA microarray to examine the mRNA expression profile of adipocytes differentiated from 3T3-L1 cells treated with SQ and its EG derivatives. Enrichment analyses of the transcriptional data showed that compared with SQ, its EG derivatives exerted different, in most cases desirable, biological responses.

Effect of Alkali Metal Cations on the Unilamellar Vesicle of a Squalene Bearing 18-Crown-6.

Squalene bearing 18-crown-6 was synthesized and formed unilamellar vesicles with a membrane thickness of about 6 nm and a diameter of about 0.32 μm. In the wake of the recognition of alkali metal cations, squalene unilamellar vesicles become larger as multilamellar vesicles or smaller while maintaining unilamellar vesicles depending on cations.

Microalgae extract induces antidepressant-like activity via neuroinflammation regulation and enhances the neurotransmitter system.

The increasing prevalence of mental disorders, such as depression, is currently a serious public health concern. Microalgae are a diverse group of organisms that contain many bioactive compounds such as polyunsaturated fatty acids and polyphenols. These compounds can exhibit many health benefits such as antioxidative, anti-inflammatory, anticancer, and anti-obesity effects.

Elucidation of the Potential Hair Growth-Promoting Effect of , Its Novel Compound Methylated-Meijicoccene, and C32 Botryococcene on Cultured Hair Follicle Dermal Papilla Cells Using DNA Microarray Gene Expression Analysis.

A person's quality of life can be adversely affected by hair loss. Microalgae are widely recognized for their abundance and rich functional components. Here, we evaluated the hair growth effect of a green alga, (), in vitro using hair follicle dermal papilla cells (HFDPCs).

New Amphiphilic Squalene Derivative Improves Metabolism of Adipocytes Differentiated From Diabetic Adipose-Derived Stem Cells and Prevents Excessive Lipogenesis.

Squalene (Sq) is a natural compound, found in various plant oils, algae, and larger quantity in deep-sea shark liver. It is also known as an intermediate of cholesterol synthesis in plants and animals including humans. Although evidences demonstrated its antioxidant, anticancer, hypolipidemic, and hepatoprotective and cardioprotective effects, its biological effects in cellular function might have been underestimated because of the water-insoluble property.

Synthesis of 2-(2-Hydroxyethoxy)-3-hydroxysqualene and Characterization of Its Anti-Inflammatory Effects.

Squalene (SQ), a natural precursor of many steroids, can inhibit tumor progression and decrease serum cholesterol levels. However, it is difficult to discern the effect of highly active molecules in the treatment of diseases because not enough active compounds reach the site of pathology in crowded biosystems. Therefore, it is necessary to design artificial probes that work effectively within crowded systems.

Anisotropic Self-Oscillating Reaction in Liquid Crystalline Nanosheet Hydrogels.

Anisotropic chemical wave propagation of self-oscillating Belousov-Zhabotinsky (BZ) reaction was demonstrated in the poly( N-isopropylacrylamide) gel films embedded with macroscopically aligned liquid crystalline inorganic nanosheets. Although the average propagation rate of chemical wave v̅ was 3.56 mm min in the gels without nanosheets, the propagation was retarded in the gels with 1 wt % of nanosheets: [Formula: see text] = 1.

Electrochemically Switchable Molecular-Tweezers.

Synthetic receptors possessing two complexing chromophores connected by a single spacer are referred to as molecular tweezers. We report an electrochemically triggered molecular tweezers, which is a calix[4]arene-bis-porphyrin conjugate, that acts as a proof-of-concept demonstration system showing an electro-statically induced approach to guest release. The electrochemical behavior represents that 1,4-diazabicyclo[2.

A self-oscillating gel actuator driven by ferroin.

In the wake of the Belousov-Zhabotinsky reaction catalyzed by ferroin, the swelling-deswelling oscillating soft actuator exhibits 7 min period of self-oscillation for the first time.

[Photocurrent generators derived from non-covalently assembled soft-matter molecular system].

It is rather difficult to design a multilayer photocurrent generator system on the ITO electrode, however, the preparation of thin film with high surface concentration of donor units is indispensable in order to achieve high conversion efficiency. The polymer film of porphyrin bearing pyroles on the electrode was prepared by the potential sweep method. It was indicated that the self-aggregation can be suppressed by encapsulation of the porphyrin unit in the cavity of macro-cyclic host molecule, cyclodextrin.

13C NMR longitudinal relaxation time studies of a molecular tweezers derived from a calixarene-porphyrin conjugate.

Zn(II)porphyrin-substituted calix[4]arene 1 serves as molecular tweezers for 1,4-diazabicyclo[2.2.2] octane (DABCO) selectively, which led to the formation of Ensemble I.

Syntheses and characterizations of a new calixarene-porphyrin conjugate as electron transfer system.

A new calixarene-based donor-acceptor system, cone conformer 1, was prepared for the first time. In this compound, the calix[4]arene serves to juxtapose a tri-chloroquinone acceptor near the porphyrin photo-donor plane. As to the conformational control, the cone conformer 1 gave two peaks of phenolic OH groups at 8.

Effects of interleukin-8 and Helicobacter pylori on histamine release from isolated canine gastric mucosal mast cells.

Background: In recent studies, the involvement of mast cells in the pathogenesis of Helicobacter pylori infection was suggested. In the present study, using isolated canine gastric mucosal mast cells, we undertook to elucidate the effects of interleukin-8 (IL-8) and H. pylori on histamine release from these cells.