Publications by authors named "Takao Sugihara"
We investigated the drug resistance status of Pseudomonas aeruginosa (P. aeruginosa) focusing on its isolation sites and types of diseases. Materials and methods: A microbiological laboratory database was searched to identify all clinical cultures positive for P.
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- Laser thermal therapy is a promising treatment for malignant tumors, utilizing a new laparoscopic system that incorporates an ultra-compact thermo-sensor for precise temperature control.
- The researchers conducted experiments on Sprague-Dawley rats with implanted hepatocellular carcinoma, where six rats received the thermal therapy that maintained a stable temperature of 70 °C for five minutes.
- Results showed that tumors treated with the laparoscopic laser system had significantly smaller volumes compared to untreated tumors, demonstrating its effectiveness in targeting cancer tissues.
Background: Postoperative subcutaneous emphysema (SE) is a possible complication of thoracoscopic or laparoscopic surgery. This study investigated the risk factors and clinical significance of SE after video-assisted thoracoscopic surgery for esophageal cancer (VATS-e).
Methods: This study included 135 patients who underwent VATS-e with artificial CO pneumothorax.
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- The study aimed to assess the tolerability of neoadjuvant chemotherapy (NAC) in elderly patients (≥ 76 years) with esophageal cancer, as previous trials excluded this age group despite showing survival benefits.
- Out of 174 patients, those aged 76 and older (E group) received NAC less frequently and had a lower completion rate compared to younger patients (Y group), along with lower relative dose intensity (RDI) of the chemotherapy drugs used.
- Elderly patients experienced more severe adverse events, particularly neutropenia, suggesting they may be more sensitive to the toxic effects of NAC, indicating the need for careful case selection and potential dose adjustments for this demographic.
Background: Serum and tissue human epidermal growth factor receptor 2 (HER2) levels were evaluated in resected esophageal squamous cell carcinoma (SCC) specimens to assess the relationship between HER2 expression and long-term prognosis.
Methods: We included 95 patients who underwent esophagectomy for esophageal SCC. The serum HER2-extracellular domain (sHER2-ECD) levels were measured using an ELISA kit.
Platelet-related measures are considered important in predicting long-term outcomes in patients with esophageal squamous cell carcinoma (ESCC). We performed a systematic electronic research of studies evaluating the prognostic value of platelet-related measures in ESCC in Google Scholar, PubMed, Cochrane Library, and Embase. Then, to synthesize publications exploring the association between platelet-related measures and survival outcomes in ESCC, a meta-analysis was conducted using hazard ratio and 95 % confidence interval.
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- * The procedure involved creating artificial pneumothorax and careful dissection while preserving critical blood vessels, with the left-side operation taking 54 minutes and resulting in minimal blood loss.
- * No cancer recurrence was observed 24 months post-surgery, highlighting the safety and effectiveness of this minimally invasive approach for esophageal cancer patients with isolated lymph node metastasis.
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- The study examined how laparoscopic gastrectomy (LG) influences long-term survival for gastric cancer patients, especially those dealing with postoperative infectious complications (PIC).
- 608 patients were divided into two groups: those who had LG (385 patients) and those who had open gastrectomy (OG: 211 patients), then survival outcomes were compared based on the presence of PIC.
- Results showed that while PIC worsened survival outcomes in OG patients, it did not significantly affect the overall survival in LG patients, indicating that LG might have a better prognosis despite complications.
Background: The aim of this study was to investigate the impact of postoperative infectious complications on adjuvant chemotherapy administration in patients with gastric cancer.
Methods: A retrospective review of 308 patients who underwent curative resection for gastric cancer was performed. Patients were divided into two groups based on the presence (90 patients, 29.
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- - The study aimed to create a new systemic inflammatory score (SIS) using ratios like neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and C-reactive protein/albumin ratio (CAR) to predict outcomes for patients undergoing esophageal cancer surgery.
- - Involving 102 patients, it found that a higher SIS (2-3) correlated with poorer survival compared to a lower SIS (0-1), with SIS showing the best prognostic power among the measures tested (AUROC of 0.732).
- - Additionally, the high-SIS group showed significant relationships with specific cytokine levels, such as lower IL-6 and higher IL-10
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- A retrospective study was conducted to analyze how postoperative pneumonia affects skeletal muscle loss in patients who underwent esophagectomy for esophageal cancer.
- The study included 123 patients, comparing those with pneumonia (30) to those without (93), and assessed muscle volume loss and survival rates over a 6-month period.
- Results showed that patients with pneumonia experienced a significant decrease in muscle volume and worse overall survival compared to those without pneumonia, along with a higher occurrence of asymptomatic pneumonia.
Background: Trastuzumab (T-mab)-based chemotherapy is a standard regimen for human epithelial growth factor 2 (HER2)-positive gastric cancer. However, some patients have demonstrated a change in HER2 status after T-mab-based treatment of breast cancer. We report a rare case of mixed adenoneuroendocrine carcinoma with loss of HER2 positivity after T-mab-based chemotherapy for HER2-positive gastric cancer.
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- The study investigates the development of nonalcoholic fatty liver disease (NAFLD) in patients who underwent gastrectomy for gastric cancer, identifying key risk factors.
- A total of 721 patients were analyzed, revealing a NAFLD incidence of 4.85% one year post-surgery, with factors like age, BMI, and adjuvant chemotherapy linked to higher risks.
- Adjuvant chemotherapy and elevated preoperative serum cholinesterase levels emerged as independent risk factors for NAFLD development after the procedure.
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- Pneumatosis intestinalis (PI) is a rare condition that can occur following chemotherapy, as illustrated by a 70-year-old man who developed it after receiving cisplatin and 5-fluorouracil for esophageal cancer.
- After experiencing acute abdominal pain, CT scans showed extensive PI in the colon but no signs of ischemia, leading to a decision for conservative treatment.
- By Day 7, follow-up CT scans showed that the PI had resolved, allowing the patient to successfully undergo surgery without complications, highlighting the importance of recognizing and managing PI conservatively in patients undergoing CF therapy.