Psychomotor agitation in major depressive disorder is a predictive factor of mood-switching.

Background: The relationship between psychomotor agitation in unipolar depression and mood-switching from depression to manic, hypomanic and mixed states has been controversial. We investigated the future risk of initial mood-switching as a function of psychomotor agitation in unipolar depression.

Methods: We identified 189 participants diagnosed with major depressive disorder (MDD).