Publications by authors named "Takanori Tsukahara"
Article Synopsis
- - The TRPC6 gene plays a crucial role in the development of slit diaphragms in podocytes, and mutations in this gene can lead to various kidney diseases, including steroid-resistant nephrotic syndrome and focal segmental glomerulosclerosis.
- - A case study is presented involving a 2-year-old Japanese boy who experienced rapidly progressing infantile nephrotic syndrome due to a harmful variant in the TRPC6 gene, which caused severe kidney function decline.
- - The child's kidney pathology revealed diffuse mesangial sclerosis (DMS), marking the first report of a TRPC6-related kidney disorder linked to this specific condition.
Background: Low birthweight infants have a reduced number of nephrons and are at high risk of chronic kidney disease. Preterm birth and/or intrauterine growth restriction (IUGR) may also affect peritubular capillary development, as has been shown in other organs.
Case-diagnosis/treatment: We report two patients with a history of preterm birth and extremely low birthweight who showed polycythemia and renal capillary rarefaction.