Publications by authors named "Takanori Oh"
Article Synopsis
- Researchers studied apolipoprotein A2-isoforms (apoA2-is) as potential biomarkers for early-stage pancreatic cancer and developed a new diagnostic assay for them.
- The study included 2732 plasma samples and showed that apoA2-ATQ/AT has a higher ability to distinguish pancreatic cancer from healthy controls compared to the traditional biomarker CA19-9.
- ApoA2-ATQ/AT also demonstrated better sensitivity for detecting early-stage pancreatic cancers, and using it in combination with CA19-9 boosted detection rates significantly.
Clinical Profiles of Nalfurafine Hydrochloride for the Treatment of Pruritus Patients.
Handb Exp Pharmacol
November 2021
Nalfurafine hydrochloride is a selective kappa-opioid agonist that has antipruritic effects. Here we describe the clinical trials for treatment of uremic pruritus in dialysis patients and on hepatic pruritus in patients with chronic liver disease. Among cytochrome P-450 (CYP) isoforms in humans, CYP3A4 is the major isoform involved in metabolic decyclopropylmethylation of nalfurafine hydrochloride.
View Article and Find Full Text PDFAims: Patients with chronic liver disease sometimes develop cholestasis, which induces severe whole-body pruritus that may disrupt daily activities and sleep. To determine the efficacy of nalfurafine hydrochloride (5 μg), which is a selective κ-opioid receptor agonist, in improving pruritus, we undertook a double-blind placebo-controlled study in patients with chronic liver disease with refractory pruritus. Nalfurafine hydrochloride at 2.
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