Increased expression of mitochondrial respiratory enzymes in the brain of epilepsy-prone, naive EL mice.

The present studies demonstrate that expression of both type 5 and type 6 subunits of NADH dehydrogenase and the type 1 subunit of cytochrome oxidase is enhanced significantly in the brains of naive, epilepsy-prone EL mice. In contrast, no apparent change in expression occurred with type 1 and type 2 subunits of NADH dehydrogenase. When expression of type 5 and 6 subunits of NADH dehydrogenase was determined at 24 h after a single series of vestibular stimulation, significant down-regulation was detected.