Publications by authors named "Takanori Kakuya"
The epidermal growth factor receptor is the only available tyrosine kinase molecular target for treating oral cancer. To improve the prognosis of tongue squamous cell carcinoma (TSCC) patients, a novel molecular target for tyrosine kinases is thus needed. We examined the expression of interleukin-2-inducible T-cell kinase (ITK) using immunohistochemistry, and the biological function of ITK was investigated using biochemical, phosphoproteomic, and metabolomic analyses.
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- The study aimed to identify actinin-4 protein overexpression as a potential predictive biomarker for the success of platinum-combination adjuvant chemotherapy in patients with stage II-IIIA lung adenocarcinoma.
- Researchers evaluated actinin-4 levels in patients who had their tumors completely removed and compared survival outcomes between those who received adjuvant chemotherapy and those who were only observed.
- Results showed that patients with high actinin-4 levels benefited significantly from adjuvant chemotherapy, while those with low levels did not see a survival advantage, indicating that actinin-4 might help predict who will respond to treatment.
Although several clinical trials have demonstrated the benefits of platinum-combined adjuvant chemotherapy for resected non-small cell lung cancer (NSCLC), predictive biomarkers for the efficacy of such therapy have not yet been identified. Selection of patients with high metastatic ability in the early stage of non-small cell lung cancer (NSCLC) has the potential to predict clinical benefit of adjuvant chemotherapy (ADJ).In order to develop a predictive biomarker for efficacy of ADJ, we reanalyzed patient data using a public database enrolled by JBR.
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