Clinical and Genetic Findings of the First Report of PAPA Syndrome in Brazil.

Background: PAPA syndrome (MIM #604416) is a rare monogenic autoinflammatory disease genetically transmitted in an autosomal dominant trait that results from missense mutations in the proline-serine-threonine phosphatase-interactive protein 1 (PSTPIP1) gene located on chromosome 15 and is characterized by sterile pyogenic arthritis, pyoderma gangrenosum, and cystic acne. We describe the clinical and molecular findings of two related Brazilian patients with PAPA syndrome. .

Factors associated with the incomplete opportune vaccination schedule up to 12 months of age, Rondonópolis, Mato Grosso.

Objective: To analyze factors associated with the incomplete timely vaccination schedule up to 12 months of age, in children born in 2015, in the municipality of Rondonópolis, Mato Grosso.

Methods: Population survey, August/2017 to February/2018, which used the method proposed by the World Health Organization to collect information about routine vaccination. For analysis of the associated factors, the recommendations of the National Immunization Program of the Ministry of Health were considered.

A new genus and species of pigeon (Aves, Columbidae) from the Kingdom of Tonga, with an evaluation of hindlimb osteology of columbids from Oceania.

The region from New Guinea through Oceania sustains the world's most diverse set of columbids. We describe osteological characters of the hindlimb (femur, tibiotarsus, tarsometatarsus) that divide the Papuan-Oceanic pigeons and doves into three groups based on functional morphology: "arboreal" (Hemiphaga, Ducula, Ptilinopus, Drepanoptila, Gymnophaps), "intermediate" (Columba, Macropygia, Reinwardtoena), and "terrestrial" (Gallicolumba [includes Alopecoenas], Trugon, Microgoura, Goura, Chalcophaps, Geopelia, Henicophaps, Caloenas, Didunculus, Otidiphaps). The arboreal and terrestrial groups are each distinctive osteologically, especially in the tibiotarsus and tarsometatarsus, which are short relative to the femur in the arboreal group, and long relative to the femur in the terrestrial group.

Red imported fire ant (Solenopsis invicta) aggression influences the behavior of three hard tick species.

Few studies have documented the indirect effects of predators on tick behavior. We conducted behavioral assays in the laboratory to quantify the effects of a highly abundant predator, the red imported fire ant (Solenopsis invicta), on three species of ticks endemic to the southern USA: the lone star tick (Amblyomma americanum), the Gulf Coast tick (A. maculatum), and the Cayenne tick (A.

Acquisition of specific antibodies and their influence on cell-mediated immune response in neonatal cord blood after maternal pertussis vaccination during pregnancy.

Maternal immunization with pertussis acellular vaccine (Tdap) is an intervention that provides protection to newborns. However, it has been reported that high maternal antibody levels may adversely affect the immune response of infants after active immunization. In this study, we evaluated neonatal passive acquisition of pertussis-specific antibodies and their influence on the neonatal cell-mediated immune response.

Another new species of flightless Rail (Aves: Rallidae: Rallus) from Abaco, The Bahamas.

We describe a late Pleistocene species of extinct rail, Rallus gracilipes n. sp., from Sawmill Sink blue hole on Abaco Island, Little Bahama Bank, The Bahamas.

Effects of goal-directed fluid therapy on enhanced postoperative recovery: An interventional comparative observational study with a historical control group on oesophagectomy combined with ERAS program.

Background And Aims: The Enhanced Recovery after Surgery (ERAS) program has been proposed as a postoperative recovery-enhancing strategy. We frequently apply the Modified-ERAS program following oesophagectomy. This study aims to elucidate the impact of goal-directed fluid therapy (GDT) for the perioperative management of oesophageal cancer on the postoperative recovery of patients undergoing oesophagectomy.

Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1α pathway.

Metastasis stands as the major obstacle for the survival from cancers. Nonetheless most existing anti-cancer drugs inhibit only cell proliferation, and discovery of agents having both anti-proliferative and anti-metastatic properties would be more beneficial. We previously reported the discovery of small-molecule Ras inhibitors, represented by Kobe0065, that displayed anti-proliferative activity on xenografts of human colorectal cancer (CRC) cell line SW480 carrying the K-rasgene.

Population-based study on infant mortality.

Although Brazil has reduced social, economic and health indicators disparities in the last decade, intra- and inter-regional differences in child mortality rates (CMR) persist in regions such as the state capital of Mato Grosso. This population-based study aimed to investigate factors associated with child mortality in five cohorts of live births (LB) of mothers living in Cuiabá (MT), Brazil, 2006-2010, through probabilistic linkage in 47,018 LB. We used hierarchical logistic regression analysis.

Passive acquisition of anti-Staphylococcus aureus antibodies by newborns via transplacental transfer and breastfeeding, regardless of maternal colonization.

Objective:: To investigate the transmission of anti-Staphylococcus aureus (Sa) IgG, IgG1 and IgG2 via placental transfer and the transfer of IgA via the colostrum according to maternal Sa carrier status at delivery.

Methods:: We evaluated anti-Sa IgG, IgG1 and IgG2 in maternal and cord sera and IgA in colostrum from a case (n=49, Sa+) and a control group (n=98, Sa-).

Results:: Of the 250 parturients analyzed for this study, 49 were nasally colonized with S.

An Assessment of Host Associations, Geographic Distributions, and Genetic Diversity of Avian Chewing Lice (Insecta: Phthiraptera) from Benin.

Host associations of highly host-specific chewing lice (Insecta: Phthiraptera) across multiple avian species remains fairly undocumented in the West African country of Benin. Two hundred and seventeen bird specimens collected from multiple localities across Benin and housed at the Texas A&M University Biodiversity Research and Teaching Collections were examined for lice. Lice were identified and genetic data (mitochondrial COI and nuclear EF-1α genes) were obtained and phylogenetically analyzed.

A new extinct species of Snipe (Aves: Scolopacidae: Gallinago) from the West Indies.

We describe an extinct species of snipe (Gallinago kakuki, new species) from late Quaternary fossils in the Bahamian Archipelago (Abaco, New Providence, Little Exuma, Long, and Middle Caicos islands). The new species is known as well from fossils on Cuba, and Cayman Brac in the Cayman Islands. This rather large species of snipe was volant, although because of its relatively short carpometacarpus, the primary flight feathers probably were short.

A new species of Woodcock (Aves: Scolopacidae: Scolopax) from Hispaniola, West Indies.

Several hundred late Holocene fossils from Trouing Jean Paul, a cave in Massif de la Selle, Haiti, represent an extinct species of woodcock (Scolopax brachycarpa, new species). Scolopax brachycarpa is known from most major skeletal elements; although volant, its carpometacarpus was very short relative to its humerus. The only other species of Scolopax from the West Indies is the extinct and presumably closely related S.

Doctors' awareness concerning primary immunodeficiencies in Brazil.

Background: PIDs are a heterogeneous group of genetic illnesses, and delay in their diagnosis is thought to be caused by a lack of awareness among physicians concerning PIDs. The latter is what we aimed to evaluate in Brazil.

Methods: Physicians working at general hospitals all over the country were asked to complete a 14-item questionnaire.

[Prevalence and clinical characteristics of wheezing in children in the first year of life, living in Cuiabá, Mato Grosso, Brazil].

Objective:: To evaluate the prevalence and the clinical characteristics of wheezing in infants aged 12 to 15 months in the city of Cuiabá, Mato Grosso State, Midwest Brazil.

Methods:: Parents and/or guardians of infants were interviewed and completed a written standardized questionnaire of the Estudio Internacional de Sibilancia en Lactantes (EISL) - phase 3 at primary healthcare clinics at the same day of children vaccination or at home, from August of 2009 to November of 2010.

Results:: 1,060 parents and/or guardians completed the questionnaire, and 514 (48.

Severe combined immunodeficiency in Brazil: management, prognosis, and BCG-associated complications.

Background: Severe combined immunodeficiency (SCID) is one of the most severe forms of primary immunodeficiency. The objectives of this study were to analyze the diagnosis, treatment, and prognosis of SCID in Brazil and to document the impact of BCG vaccine.

Methods: We actively searched for cases by contacting all Brazilian referral centers.

Risk factors associated with wheezing in infants.

Objective: to identify possible risk factors associated with wheezing in infants (12-15 months-old) in the state of Mato Grosso, Brazil.

Methods: this was a cross-sectional study performed by applying a standardized written questionnaire from the international study on wheezing in infants (Estudio Internacional de Sibilancia en Lactantes - EISL), phase 3. Parents and/or guardians of infants were interviewed at primary health care clinics or at home from August of 2009 to November of 2010.

The effect of intraoperative use of high-dose remifentanil on postoperative insulin resistance and muscle protein catabolism: a randomized controlled study.

Objective: We investigated the effect of the intraoperative use of a high dose remifentanil on insulin resistance and muscle protein catabolism.

Design: Randomized controlled study.

Patients And Intervention: Thirty-seven patients undergoing elective gastrectomy were randomly assigned to 2 groups that received remifentanil at infusion rates of 0.

A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells.

Germline cells reprogramme extensive epigenetic modifications to ensure the cellular totipotency of subsequent generations and to prevent the accumulation of epimutations. Notably, primordial germ cells (PGCs) erase genome-wide DNA methylation and H3K9 dimethylation marks in a stepwise manner during migration and gonadal periods. In this study, we profiled DNA and histone methylation on transposable elements during PGC development, and examined the role of DNA replication in DNA demethylation in gonadal PGCs.

Skin rubdown with a dry towel, 'kanpu-masatsu' is an aerobic exercise affecting body temperature, energy production, and the immune and autonomic nervous systems.

Skin rubdown using a dry towel (SRDT) to scrub the whole body is a traditional therapy for health promotion. To investigate its mechanism, 24 healthy male volunteers were studied. Body temperature, pulse rate, red blood cells (RBCs), serum levels of catecholamines and cortisol, blood gases (PO(2), sO(2), PCO(2) and pH), lactate and glucose, and the ratio and number of white blood cells (WBCs) were assessed before and after SRDT.

[Asthma prevalence and risk factors in adolescents 13 to 14 years of age in Cuiabá, Mato Grosso State, Brazil].

The objective of this study was to estimate the prevalence of active asthma and identify associated risk factors in adolescents 13 to 14 years of age in Cuiabá, Mato Grosso State, Brazil. A cross-sectional population-based and a subsequently a nested case-control study was conducted in 2008 using the protocol of the International Study of Asthma and Allergies in Childhood (ISAAC). Risk factor analysis used the chi-square test, Fisher's exact test, and binary logistic regression.