Publications by authors named "Takamitsu Bakoshi"
The mechanism of action of Spi-B in the transcriptional activation of the interferon-α4 gene.
Biochem Biophys Res Commun
April 2020
Article Synopsis
- Plasmacytoid dendritic cells (pDCs) are important immune cells that produce type I interferon in response to nucleic acid sensing receptors TLR7 and TLR9, playing a key role in antiviral immunity and autoimmune diseases.
- A transcription factor called Spi-B, highly expressed in pDCs, is essential for enhancing type I interferon production through TLR7/9 signaling by interacting with another factor, IRF-7.
- This study investigates how Spi-B interacts with the Ifna4 promoter, revealing its binding near the IRF-7 site and showing that Spi-B's collaboration with the coactivator p300 is crucial for boosting the promoter's activity.