Publications by authors named "Takamichi Shigaki"
Article Synopsis
- MC710 is a mixture of plasma-derived activated factor VII (FVIIa) and factor X (FX), designed to manage bleeding in hemophilia patients with inhibitors.
- Pharmacokinetic studies on male rats showed that after a single dose, FVIIa and FX had half-lives of approximately 0.7-6.3 hours and 3.0-4.1 hours, respectively, with significant radioactivity in the plasma.
- About 80% of the administered radioactivity was excreted through urine and feces within 168 hours, while the tissue distribution indicated accumulation of FVIIa and FX in bone and bone marrow.
Although fibrin sealant (FS) has an advantage of high biocompatibility, its adhesive force and sealing effect have been generally considered to be inadequate. In the present study, a high adhesive force and sealing effect were obtained by first rubbing fibrinogen solution into the target tissue, attaching polyglycolic acid (PGA) felt to the treated area, and finally spraying it with FS. This method was compared with three conventional FS application methods and a method using fibrin glue-coated collagen fleece.
View Article and Find Full Text PDFThe safety and effectiveness of a Vero cell-derived inactivated Japanese encephalitis (JE) vaccine were compared with those of a current JE vaccine in non-clinical studies and a phase I clinical trial. The single-dose toxicity study showed no toxicity of either the current JE vaccine or the investigational Vero cell-derived JE vaccine. In a local irritation study, the degree of irritation caused by both vaccines was determined to be the same as that induced by normal saline.
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