Impact of Selected Initial Titration Schedules on Safety and Long-Term Effectiveness of Lamotrigine for the Treatment of Mood Disorders.

Purpose: Lamotrigine (LTG) is used for treatment of mood disorders, but it is associated with the risk of rash occurrence in the initial administration phase. Although slow titration reduces this risk, its effectiveness in the treatment of mood disorders has not been verified. The effects of titration method on the safety and effectiveness of LTG for the treatment of mood disorders were examined in this study.

[Endocrine disorders and metabolic disorders].

Psychiatric symptoms associated with endocrine disorders and metabolic disorders have been well recognized. Common endocrine/metabolic disorders that frequently cause psychiatric symptoms, thyroid disease, adrenal disorders, parathyroid disease, diabetes, electrolyte disturbance are reviewed, especially focusing on usage of psychotropic medicine. Psychotropic medication targeting each psychiatric symptom would be recommended for patients with moderate to severe psychiatric symptoms.