Biocompatibility of an experimental glass-ionomer cement sealer in rat mandibular bone.

Objective: The purpose of this study was to compare an experimental glass-ionomer cement sealer, KT-308, with a conventional zinc oxide-eugenol sealer, Canals, in terms of tissue compatibility and solubility.

Study Design: Tissue reactions were examined under light and electron microscopes at 3 and 20 days after the implantation of either freshly mixed KT-308 sealer or Canals sealer into prepared cavities in rat mandibles.

Results: At 3 days after implantation, no inflammatory reaction was seen around KT-308 sealer, which was in direct contact with the bone surface.