[Association between health literacy and behavior regarding health checkups and health counseling in Japanese employees: A comprehensive health literacy survey of a Japanese railway company].

Background: Globally, health literacy is considered important for healthy ageing. However, to our knowledge, no study has investigated comprehensive health literacy in Japanese employees.

Objective: This study aimed to examine comprehensive health literacy in employees of company A, a Japanese railway company, and to determine the association between health literacy and behavior regarding health checkups and health counseling in the employees.

Anti-tumor effects of mAb against L-type amino acid transporter 1 (LAT1) bound to human and monkey LAT1 with dual avidity modes.

L-Type amino acid transporter 1 (LAT1) disulfide linked to CD98 heavy chain (hc) is highly expressed in most cancer cells, but weakly expressed in normal cells. In the present study, we developed novel anti-LAT1 mAbs and showed internalization activity, inhibitory effects of amino acid uptake and cell growth and antibody-dependent cellular cytotoxicity, as well as in vivo antitumor effects in athymic mice. Furthermore, we examined the reactivity of mAbs with LAT1 of Macaca fascicularis to evaluate possible side-effects of antihuman LAT1 mAbs in clinical trials.

[A case of adult-onset type II citrullinemia in an elderly patient].

A 72-year-old man presented with consciousness disturbance. The results of brain magnetic resonance imaging and cerebrospinal fluid examination were normal, but triphasic waves were noted on electroencephalography. His plasma ammonia level was elevated due to which encephalopathy secondary to hyperammonemia was suspected.