Efficacy against Lung Cancer Is Augmented by Combining Aberrantly N-Glycosylated T Cells with a Chimeric Antigen Receptor Targeting Fragile X Mental Retardation 1 Neighbor.

The adaptive transfer of T cells redirected to cancer cells via chimeric Ag receptors (CARs) has produced clinical benefits for the treatment of hematologic diseases. To extend this approach to solid cancer, we screened CARs targeting surface Ags on human lung cancer cells using (to our knowledge) novel expression cloning based on the Ag receptor-induced transcriptional activation of IL-2. Isolated CARs were directed against fragile X mental retardation 1 neighbor (FMR1NB), a cancer-testis Ag that is expressed by malignant cells and adult testicular germ cells.

Physical function decline predictors in nursing home residents using new national quality indicators.

Aim: To determine the predictors of physical function (PF) decline among nursing home residents using items from the Long-term care Information system For Evidence (LIFE), a system launched in 2021 to ensure the quality of long-term care.

Methods: The LIFE data of 1648 residents from 45 nursing homes in Japan were retrospectively collected in July 2021 (T0) and January 2022 (T1), including demographics, PF assessed by the Barthel index (BI), nutrition and oral health, and cognitive function. The Dementia Behavior Disturbance scale was used to assess the frequency of certain behaviors, such as "waking at midnight.

Unplanned Hospital Visits and Poor Oral Health With Undernutrition in Nursing Home Residents.

Objectives: In 2021, the Japanese government began operating a long-term care (LTC) database called the Long-Term Care Information System for Evidence (LIFE). However, its utility has not been verified. Regarding unplanned hospital visits of nursing home residents, one of the challenges in LTC is that poor oral health with undernutrition could indicate high-risk residents.

Psychological and educational support for cancer patients who return to work: A scoping review.

Background: Many patients with cancer experience challenges when they return to work (RTW) following cancer diagnosis and treatment. Psycho-educational support is important to facilitate the RTW process.

Objective: This scoping review examined published reports on psycho-educational support for patients with cancer who RTW.

Factors related to a sense of security with medical and long-term care services among community-dwelling middle-aged and older adults in Japan.

Aim: The aim of this study was to identify factors related to a sense of security with regard to medical and long-term care services among middle-aged and older adults. These are for consideration of strategies for the establishment of a community-based integrated care system.

Methods: A cross-sectional survey was conducted in 2400 men and women aged ≥40 years in two cities.

Factors Related to End-of-Life Care Discussions Among Community-Dwelling People in Japan.

Context: End-of-life discussions regarding healthcare preferences are important to ensure a dignified end of life.

Objectives: This study clarifies the factors associated with such discussions among community-dwelling people in Japan.

Methods: We conducted a cross-sectional survey of 2400 randomly selected community-dwelling adults over the age of 40 in one urban and rural area each, in Japan.

Measuring well-being in older adults: Identifying an appropriate single-item questionnaire.

Aim: As the older adult population increases globally, it is important for local governments to measure their health and well-being consistently to effectively support this group. Because definitions of subjective well-being - such as happiness, life satisfaction and subjective health - overlap, it is worth considering which single-item indicator local governments can rely on to measure individual well-being. This study, therefore, explored the correlation between three single-item questionnaires on happiness, life satisfaction and subjective health used in government surveys, and established psychometric scales of happiness, life satisfaction and quality of life, and analyzed which of the three single-item indicators most effectively captured the target well-being.

Predictors of home being the preferred place of death among Japanese older people: JAGES cross-sectional study.

Aim: There is a large discrepancy between people's preferred and actual place of death in Japan. To manage this discrepancy, this study aimed to identify the variability in preferred places of death and their associated factors among Japanese older people.

Methods: Cross-sectional survey data were collected in 2016 as part of the Japan Gerontological Evaluation Study, in which 20 204 participants were asked about their preferred place of death.

LRRK2 regulates endoplasmic reticulum-mitochondrial tethering through the PERK-mediated ubiquitination pathway.

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common cause of familial Parkinson's disease (PD). Impaired mitochondrial function is suspected to play a major role in PD. Nonetheless, the underlying mechanism by which impaired LRRK2 activity contributes to PD pathology remains unclear.

Advance care planning and home death in patients with advanced cancer: a structured interview analysis.

Background:: Discrepancy between preferred and actual place of death is common in patients with advanced cancer.

Aim:: To investigate the association between advance care planning (ACP) and home death in patients with advanced cancer.

Methods:: Using structured interviews, 44 primary nurses from 19 home-visit nursing agencies in Japan were asked about status changes for 123 advanced cancer patients receiving home care.

Efficacy of Juzentaihoto for Tumor Immunotherapy in B16 Melanoma Metastasis Model.

. Medical care for Japanese cancer patients includes Western and Kampo medicines, and treatments with juzentaihoto (JTT) reportedly prevent cancer metastasis and recurrence. In this study, we examined the effects of JTT on natural killer (NK) cell activity and metastasis in combined treatments with anti-PD-1 antibody in a mouse model of melanoma metastasis.

Do Symptoms among Home Palliative Care Patients with Advanced Cancer Decide the Place of Death? Focusing on the Presence or Absence of Symptoms during Home Care.

Objective: Our goal was to investigate the association between actual place of death among Japanese home end-of-life care patients with advanced cancer and individual, illness, and environmental factors, including the presence or absence of symptoms.

Methods: Using structured interviews, we asked 44 nurses from 19 home-visit nursing agencies about changes in status of all 123 of their home end-of-life care patients with advanced cancer between April and September 2013. The main outcome variable was actual place of death (Home/Hospital/Still surviving) and independent variables were the patient's symptoms as a time-dependent variable.

Survey on the use of health consultation services provided in a Japanese urban public housing area with a high elderly population.

Objective: The aim of the present study was to determine how the elderly in an urban public housing area intends to utilize health consultation services.

Methods: In December 2011, a cross-sectional posting survey was carried out on 2000 randomly selected elderly residents in an urban public housing area in Japan. The survey included information on the intention of use of health consultation services provided in the community, demographic background, living situation, medical and social care situation, and the concerns and desires about the services.

[Age differences in decision-making factors on end-of-life care location for Musashino-city residents].

Objectives: Japan is predicted to continue its fast-aging trend, especially in urban areas. Therefore, promoting end-of-life services in urban areas is an urgent policy issue. In addition, the recognition of end-of-life care greatly varies by age.

[The need for health consultation services and related factors among non-users of health consultation services residing in urban public apartment complexes].

Objectives: The aim of this study was to identify the factors associated with the need for health consultation services among non-users of such services within residents of urban public apartment complexes.

Methods: In December 2011, a cross-sectional mail survey was conducted with the inclusion of 2,000 elderly residents, randomly selected from a total of 6,000 residents. We asked about the need for health consultation services, demographic data, daily living situation, medical and care-giving experiences, and health concerns and desires.

Changes of blood fluidity in the early hepatopathy in rats.

The present study was designed to examine the influence of the early stage hepatopathy on blood fluidity by using a rat experimental system. F344 male rats, 4 weeks of age, were fed chow containing 3'-methyl-4-dimethylaminoazobenzene (DAB) at 0.06%.

Endosomal sorting by Semaphorin 4A in retinal pigment epithelium supports photoreceptor survival.

Photoreceptor cell death is the hallmark of a group of human inherited retinal degeneration. Although the causative genetic mutations are often known, the mechanisms leading to photoreceptor degeneration remain poorly defined. Here, we show that Semaphorin 4A (Sema4A), a member of axonal guidance molecule semaphorin, plays a role in Rab11/FIP2-mediated endosomal sorting in retinal pigment epithelial cells to support photoreceptor function.

Suppressive effect of juzentaihoto on vascularization induced by b16 melanoma cells in vitro and in vivo.

Juzentaihoto (JTT) is well known to be one of Japanese herbal medicines, and used for the supplemental therapy of cancer patients with remarkable success. The present study, therefore, was undertaken to examine the possible therapeutic mechanisms of JTT on cancer using B16 melanoma cell (B16 cell)/experimental mouse system. JTT was well mixed with rodent chow at 3.