Publications by authors named "Takaki Kawachi"
Article Synopsis
- The study aimed to create an amorphous solid dispersion (ASD) of meloxicam (MEL) using various polymers to achieve faster drug action.
- MEL/Eudragit EPO (MEL/EPO) proved to be the most stable formulation, maintaining its properties even under challenging conditions, while other formulations showed signs of recrystallization.
- The MEL/EPO formulation not only inhibited crystal growth of MEL due to polymer interactions but also significantly enhanced drug dissolution and bioavailability in rats, leading to a 2.4-fold increase compared to crystalline MEL.
The present study aimed to develop nanocrystal formulations of meloxicam (MEL) in order to enhance its biopharmaceutical properties and provide a rapid onset of action. Nanocrystal formulations were prepared by wet-milling and lyophilization with hydrophilic polymers used as aggregation inhibitors. Aggregation inhibitors were selected based on high-throughput screening of crystal growth inhibition in supersaturated MEL solution.
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