Publications by authors named "Takahito Shinba"
Article Synopsis
- The study investigates the prevalence and factors associated with red blood cell (RBC) alloimmunization in transfused patients, focusing on how clinical factors relate to the development and disappearance of RBC antibodies.
- Data from 1194 patients across five institutions showed that 4.6% developed new antibodies after transfusion, with the number of RBC units transfused significantly influencing this outcome.
- The research suggests that antibodies identified through specific testing methods may often fade away quickly and emphasizes the importance of thorough antibody screening, particularly for patients receiving many transfusions, to avoid missing potentially relevant antibody information.
Background And Objectives: Anti-CD38 monoclonal antibodies, including daratumumab and isatuximab, often interfere with pretransfusion testing. Dithiothreitol (DTT) treatment of red blood cells (RBCs) negates this interference. However, the optimum DTT concentration and treatment time have not been well defined.
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