Publications by authors named "Takahito Kuroda"
Article Synopsis
- * The study investigates how galectin-3 behaves in the liver following acute injury caused by a synthetic substance, alpha-galactosylceramide, examining its expression levels over several days after injection.
- * Results showed that galectin-3 forms specific cell clusters in the liver during the early phase of injury, particularly noticeable on day 2, and its serum levels could serve as an important indicator for early diagnosis of acute liver damage.
Heparan sulfate (HS) is a glycocalyx component present in the extracellular matrix and cell-surface HS proteoglycans (HSPGs). Although HSPGs are known to play functional roles in multiple aspects of tumor development and progression, the effect of HS expression in the tumor stroma on tumor growth in vivo remains unclear. We conditionally deleted Ext1, which encodes a glycosyltransferase essential for the biosynthesis of HS chains, using S100a4-Cre (S100a4-Cre; Ext1f/f) to investigate the role of HS in cancer-associated fibroblasts, which is the main component of the tumor microenvironment.
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