Publications by authors named "Takahisa Saiga"
Clozapine treatment of a Japanese patient during pregnancy: Effect on fetal heart rate.
Neuropsychopharmacol Rep
December 2024
Article Synopsis
- A case study of a 29-year-old Japanese woman with schizophrenia on clozapine during pregnancy showed no complications until a late incident of premature rupture of membranes, which led to an emergency cesarean section.
- The study indicates that clozapine and its metabolite norclozapine were transferred to the fetus and may have impacted fetal heart rate; it advises careful monitoring of clozapine levels and fetal health during pregnancy for better outcomes.
Dopamine supersensitivity psychosis (DSP) in patients with schizophrenia is induced by treatment with a high dosage of antipsychotics for a long time period, and it is characterized by unstable psychotic symptoms. The upregulation of dopamine D2 receptor (DRD2) provoked by antipsychotics underlies DSP. Aripiprazole does not cause an excessive blockade of DRD2 and is less likely to upregulate DRD2 by aripiprazole's dopamine partial agonistic profile.
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