NPTX-594 is a neurotoxic acylpolyamine isolated from a Madagascar Joro spider and acts as a specific blocker of glutamate receptors (GluRs). The present study reports the creation of novel NPTX-594 analogs with thiol-containing fluorophores for use as visualization probes for the analysis of the binding mode between spider toxins and GluRs, together with the result of their cricket bioassay.
View Article and Find Full Text PDFAcylpolyamine-type spider toxins are known to be potent and specific blockers against glutamate receptors (GluRs). The present study describes the syntheses and biological activities of several fluorescent-labeled analogs related to a Madagascar Joro spider toxin NPTX-594 to analyze visually the unknown interaction between spider toxins and GluRs.
View Article and Find Full Text PDFYakugaku Zasshi
July 2006
To study the structure-activity relationship of mugineic acid (MA), a phytosiderophore isolated from Hordeum velugare L. var. Minorimugi, several 2-deoxymugineic acid (DMA) analogues were synthesized.
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