Publications by authors named "Takahiro Michiba"
Background/aim: To retrospectively evaluate the efficacy and safety of modified TPEx (docetaxel 60 mg/m on day 1, cisplatin 60 mg/m on day 1, and weekly cetuximab 250 mg/m with loading dose of 400 mg/m) followed by maintenance cetuximab as first-line treatment for inoperable recurrent and/or metastatic squamous cell carcinoma of the head and neck.
Patients And Methods: We analyzed 22 Japanese patients receiving modified TPEx every 21 days for four cycles with or without prophylactic granulocyte colony-stimulating factor (G-CSF).
Results: The best overall response rate was 55% [95% confidence interval (CI)=35-73].
Article Synopsis
- HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is sensitive to radiation but traditional treatments can lead to long-term side effects, prompting a need for less toxic therapy while still ensuring effective outcomes.
- A phase 2 trial tested intensity modulated radiation therapy (IMRT) without chemotherapy on newly diagnosed OPSCC patients who were HPV-positive, focusing on their complete response 10 weeks post-treatment.
- The trial included 39 patients, 90% achieved a complete response, and showed high survival rates with very few severe side effects, suggesting IMRT could be a safer alternative for treating HPV-related OPSCC.
Article Synopsis
- An optimal imaging assessment strategy for the neck post-chemoradiotherapy is necessary to prevent unnecessary neck dissection in patients.
- A study of 101 patients found that PERCIST outperformed RECIST in positive predictive value (PPV), although both had similar negative predictive values (NPV).
- The best results for predicting regional treatment failure came from the combination of RECIST and PERCIST, especially in HPV-related oropharyngeal cancer, which showed a 100% NPV but low PPV.
Article Synopsis
- HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is characterized by the presence of p16 or HPV DNA, with patients generally showing good survival rates post-treatment, prompting interest in less aggressive therapies.
- A study involving 107 patients found that those with p16-positive/HPV DNA-negative OPSCC had significantly worse survival outcomes when treated with radiotherapy alone compared to those with p16-positive/HPV DNA-positive OPSCC, even after adjusting for other factors.
- The findings suggest that while radiotherapy alone is a viable treatment option for p16-positive/HPV DNA-positive patients, it is not effective for p16-positive/HPV DNA-negative patients, indicating the need for tailored treatment strategies based
The protein phosphatase PPM1D (Wip1) was originally identified as a p53 target product. Activation of PPM1D through various mechanism promotes the tumorigenic potential of various cancers by suppressing p53 and other DNA damage response proteins. New functions of PPM1D have recently been revealed in physiological processes such as cell differentiation.
View Article and Find Full Text PDFWe aimed to determine whether pretreatment metabolic tumor volume of the primary tumor (T-MTV) or T classification would be a better predictor of laryngectomy-free survival (LFS) and overall survival (OS) after chemoradiotherapy in patients with locally advanced laryngeal or hypopharyngeal cancer requiring total laryngectomy. We analyzed 85 patients using a Cox proportional hazards model and evaluated its usefulness by Akaike's information criterion. A T-MTV cut-off value was determined by time-dependent receiver operating characteristic curve analysis.
View Article and Find Full Text PDFDue to habitual drinking and smoking and advanced age at diagnosis, patients with head and neck squamous cell carcinoma (HNSCC) frequently present with comorbidities. Several comorbidity indices have been developed and validated for HNSCC. However, none have become the standard method.
View Article and Find Full Text PDFConclusion: The age-adjusted Charlson comorbidity index (ACCI) was associated with overall survival, disease-specific survival, and non-cancer death in patients treated with chemoradiation therapy (CRT) for hypopharyngeal cancer (HPC). Further studies using other CRT regimens are required.
Objective: To investigate the impact of the ACCI on survival in patients with HPC.
Various serum biomarkers have been developed for predicting head and neck squamous cell carcinoma (HNSCC) prognosis. However, none of them have been proven to be clinically significant. A recent study reported that the ratio of aspartate aminotransaminase (AST) to alanine aminotransaminase (ALT) had a prognostic effect on non-metastatic cancers.
View Article and Find Full Text PDFConclusions: Comorbidities as well as T classification were the primary determinants for the nutritional status of patients with head and neck cancer.
Objectives: We aimed to elucidate the underlying conditions of malnutrition in patients with head and neck cancer.
Methods: We retrospectively reviewed 726 patients diagnosed with head and neck cancer between 2004 and 2013.
Background: Patients with head and neck cancer frequently experience malnutrition. The purpose of this study was to examine the impact of nutritional status on prognosis and its association with treatment modalities.
Methods: This retrospective study included 706 patients with head and neck cancer diagnosed between 2004 and 2012.
[Significant factors for surgical site infection: analysis of 203 head and neck surgeries].
Nihon Jibiinkoka Gakkai Kaiho
February 2014
Surgical site infection (SSI) is a common complication in head and neck surgeries. The aim of this study was to assess the rate of, and risk factors for SSI following surgical procedures of the head and neck. The study population comprised 206 patients who underwent surgery of head and neck region in NTT West Osaka Hospital between 2009 and 2011.
View Article and Find Full Text PDFConclusions: To establish a system of differential diagnosis for vertigo/dizziness at the Emergency Department (ED), careful history-taking of complications and examinations of nystagmus should be helpful and therefore prepared by ED staff.
Objectives: Vertigo/dizziness could come from various kinds of organs for equilibrium, sometimes resulting in an emergency due to the central origin. In the present study, we checked patients' background data at the ED in advance of a definitive diagnosis at the Department of Otolaryngology and examined the significance of the correlation between the data and the diagnosis.
Soft tissue sarcoma arising as a head and neck lesion is very rare in adults. Therefore, no standardized treatment exists for this entity of disease. We retrospectively analyzed 11 cases of head and neck soft tissue sarcomas treated at Osaka University Hospital from 1991 to 2011.
View Article and Find Full Text PDFObjectives: Some patients with sudden sensorineural hearing loss (SSNHL) are frustrated by residual tinnitus even after accomplishment of the treatment for SSNHL. In the present prospective study, we examined patients' backgrounds of sex, laterality and age together with changes in hearing level and the tinnitus score after the onset of SSHNL to determine the prognostic factors of residual tinnitus after the final day of medical treatment for SSNHL.
Methods: Forty-four patients with SSNHL were all treated with systemic administration of steroids for 2 weeks and oral intake of vasoactive drugs and vitamin B12 for 6 months before accomplishment of the treatment for SSNHL.