Publications by authors named "Takahiro Jubashi"

Article Synopsis
  • ZEB1 is a crucial factor in cancer cell behavior, particularly in differentiation and metastasis, while the role of ZEB2 in head and neck squamous cell carcinoma (HNSCC) is less understood.
  • In experiments with mouse oral cancer (MOC) cells, both ZEB1 and ZEB2 overexpression led to a loss of epithelial traits and promoted aggressive cell behaviors.
  • Interestingly, ZEB1 overexpression was found to increase ZEB2 levels and vice versa, but ZEB2 exhibited greater potential for aggressive growth than ZEB1 in lab conditions.
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Osteosarcoma (OS) is the most common primary bone tumor in children and adolescents. Prognosis is improving with advances in multidisciplinary treatment strategies, but the development of new anticancer agents has not, and improvement in prognosis for patients with pulmonary metastases has stalled. In recent years, the tumor microenvironment (TME) has gained attention as a therapeutic target for cancer.

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Primary malignant cardiac tumors rarely occur, and cardiac synovial sarcoma (SS) is especially rare among such tumors. Herein, we present the case of a 35-year-old female with primary cardiac SS treated with surgery, chemotherapy, and radiotherapy. She presented with chest symptoms and underwent imaging examinations.

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Article Synopsis
  • Osteosarcoma (OS) hasn't improved much in treatment for 20 years, so researchers are looking for new ways to fight it.
  • Tumor-associated macrophages (TAMs) in the tumor environment produce cytokines that can help cancer grow and spread, but their exact role in OS needs more study.
  • Researchers found that a specific cytokine called IL-8, made by TAMs, boosts OS growth and spread, suggesting that targeting IL-8 could be a new way to treat this type of cancer.
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Angiomatoid fibrous histiocytoma (AFH) is a rare tumor of mesenchymal origin occurring in young adults. Based on its clinical course, it is said to have an intermediate potential. We present a case of a 59-year-old woman with AFH in the hand that was difficult to diagnose.

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Case: A 17-year-old man experienced night pain in his right hallux. Radiographs revealed a lytic lesion in the proximal phalanx of the right hallux. Magnetic resonance imaging showed a low-signal intensity mass on T1-weighted sequences and isointense-high-signal intensity on T2-weighted sequences.

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