Publications by authors named "Takahiro Ajiki"
The study aims to investigate the vitamin B6 levels in Parkinson's disease (PD) patients and their association with liver enzymes and evaluate how much dysregulation is associated with levodopa dose. Furthermore, to evaluate the effect of Opicapone, a catechol-o-methyl-transferase inhibitor, on vitamin B6 levels by monitoring the AST and ALT levels in patients treated with Levodopa-Carbidopa Intestinal Gel Infusion (LCIG). For these aims, serum vitamin B6 levels were measured (PD, n = 72 and controls, n = 31).
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- The study investigates how misfolded α-synuclein (αSyn) spreads between neurons and contributes to diseases called synucleinopathies, focusing on the role of lysosomes.
- Researchers found that when αSyn aggregates invade lysosomes, they can cause the lysosomal membrane to rupture, leading to the transmission of αSyn aggregation to other neurons.
- The process of lysophagy, which is the selective degradation of damaged lysosomes, can prevent this transmission, suggesting that maintaining healthy lysosomes is crucial in managing the progression of synucleinopathies.