Publications by authors named "Takahide Hosobe"
Article Synopsis
- A nationwide surveillance in Japan studied the antimicrobial susceptibility of bacteria in acute uncomplicated cystitis, focusing on E. coli, K. pneumoniae, and S. saprophyticus, between April 2020 and September 2021.
- The study isolated 823 bacterial strains from urine samples of 848 patients, with a majority being E. coli (92.9%), and determined susceptibility to 18 antibacterial agents.
- Results showed a concerning increase in fluoroquinolone-resistant E. coli and extended-spectrum β-lactamase (ESBL)-producing E. coli, especially in postmenopausal women, highlighting the need for clinicians to adapt their antibiotic choices due to rising resistance rates.
Neisseria gonorrhoeae is one of the important pathogens of sexually transmitted infections. N. gonorrhoeae is rapidly becoming antimicrobial resistant, and there are few drugs that are effective in the initial treatment of gonorrhea.
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- The Urogenital Sub-committee and Surveillance Committee of various Japanese health organizations conducted a nationwide study to assess how susceptible Chlamydia trachomatis is to different antibiotics by collecting clinical samples from 26 hospitals between May 2016 and July 2017.
- The study measured the minimum inhibitory concentrations (MICs) for a range of antibiotics, finding no resistant strains to fluoroquinolones, tetracyclines, or macrolides, while solithromycin showed particularly favorable MIC values.
- However, the MIC for azithromycin was slightly higher than in previous reports, suggesting the need for ongoing monitoring of its susceptibility.
The clinical efficacy of garenoxacin for male non-gonococcal urethritis.
J Infect Chemother
April 2020
Sitafloxacin (STFX) is an alternative treatment against azithromycin-resistant Mycoplasma genitalium (MG), whereas STFX-resistant MG have appeared recently. Therefore, another antimicrobial regimen for non-chlamydial non-gonococcal urethritis (NGU) is required. Garenoxacin (GRNX) is a fluoroquinolone against respiratory infections, not against urethritis in Japan, but its in-vitro antimicrobial activity against MG is known as similar to or higher than that of moxifloxacin.
View Article and Find Full Text PDFThe Japanese Surveillance Committee conducted a second nationwide surveillance of antimicrobial susceptibility patterns of uropathogens responsible for acute uncomplicated cystitis (AUC) in premenopausal patients aged 16-40 years old at 31 hospitals throughout Japan from March 2015 to February 2016. In this study, the susceptibility of causative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus saprophyticus) for various antimicrobial agents was investigated by isolation and culturing of organisms obtained from urine samples. In total, 324 strains were isolated from 361 patients, including E.
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- * A surveillance study conducted in Japan collected urethral discharge samples from patients in 2009 and 2012 to test for antibiotic resistance in C. trachomatis isolates.
- * Results showed that no resistant strains were found against common antibiotics like fluoroquinolones, tetracyclines, or macrolides during both years of the study.
Worldwide, the most important concern in the treatment of sexually transmitted infections is the increase in antimicrobial resistant Neisseria gonorrhoeae strains including resistance to cephalosporins, penicillins, fluoroquinolones or macrolides. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the second nationwide surveillance study.
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- A clinical trial conducted from 2011-2013 evaluated the effectiveness of a single 2 g oral dose of azithromycin extended-release in treating urethritis in heterosexual males, showing a 90.9% eradication rate in patients with gonococcal urethritis.
- The study found that Neisseria gonorrhoeae strains showed strong susceptibility to various antibiotics, with azithromycin having a lower susceptibility rate at 37.2%.
- While the treatment was largely effective (90% eradication rate for nongonococcal urethritis), the main side effect was temporary diarrhea, and ongoing monitoring of antimicrobial resistance in Neisseria gonorrhoeae and Mycoplasma
Neisseria gonorrhoeae is one of the most important pathogens causing sexually transmitted infection, and strains that are resistant to several antimicrobials are increasing. To investigate the trends of antimicrobial susceptibility among N. gonorrhoeae strains isolated from male patients with urethritis, a Japanese surveillance committee conducted the first nationwide surveillance.
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- A nationwide surveillance study conducted in Japan from April 2009 to November 2010 examined antimicrobial susceptibility patterns of uropathogens causing acute uncomplicated cystitis in women, involving 43 hospitals.
- The study identified E. coli as the most common bacteria (77.8%) in urine samples, with significant occurrences of S. saprophyticus in premenopausal women, while also analyzing their resistance to 19 antimicrobial agents.
- Results indicated high susceptibility of E. coli to fluoroquinolones and cephalosporins, but a rising trend in fluoroquinolone-resistant and ESBL-producing strains highlights the need for careful selection of empirical treatments based on patient characteristics.
We investigated the efficacy and safety of levofloxacin (LVFX) 500mg once a day in patients with non-gonorrheal urethritis. Men, aged 20 years or older, with urethritis symptoms, and detection of Chlamydia trachomatis (C. trachomatis) or Mycoplasma genitalium (M.
View Article and Find Full Text PDFWe investigated the enhancement of the antimicrobial activities of beta-lactams against cefixime (CFIX)-resistant Neisseria gonorrhoeae in the presence of macrolides. Ten strains of CFIX-resistant N. gonorrhoeae, isolated between 2000 and 2003 from male patients with urethritis at Jikei University Affiliated Hospital and its related clinics in the Tokyo metropolitan area, were tested.
View Article and Find Full Text PDFThe isothermal and chimeric primer-initiated amplification of nucleic acids (ICAN) is a new isothermal DNA amplification method composed of exo Bca DNA polymerase, RNaseH and DNA-RNA chimeric primers. We developed the simultaneous detection system for Chlamydia trachomatis/Neisseria gonorrhoeae DNA, combined with luminescence detection by a probe hybridization. In the performance tests, this system was able to detect 10 to 100 copies of C.
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