[Hemorrhagic radiation cystitis: a transurethral treatment with formalin-soaked pledgets].

An 80-year-old woman presented with gross hematuria and clot retention about 20 years after postoperative radiation therapy for uterine cancer. Endoscopic evaluation revealed a hyperemic bladder mucosa and bleeding foci localized to the posterior wall. Electrocauterization and continuous bladder irrigation with normal saline failed to resolve the hemorrhage, Maalox (aluminum hydroxide/magnesium hydroxide) was instilled intravesically.

Effect of erythropoietin on Leydig cell is associated with the activation of Stat5 pathway.

In order to elucidate whether erythropoietin (EPO) influences male reproduction, EPO activation via erythropoietin receptor (EPOR) of Stat5 was studied in Leydig cell cultures. RT-PCR analysis of mRNA that had been prepared from primary rat Leydig cell culture and the mouse Leydig tumor cell line (I-10 cells) each demonstrated amplification of the appropriate fragment for the respective genes. Both I-10 cells and primary rat Leydig cell cultures were treated with 1U/ml recombinant human erythropoietin (rHuEPO) for various time periods upto 60 min, and cytoplasmic proteins, total cellular proteins, and nuclear extracts were isolated.

Distribution of type IV collagen subtypes in human testes and their association with spermatogenesis.

Objective: To evaluate the expression of type IV collagen [alpha1(IV) to alpha6(IV)] in testes and the association with spermatogenesis.

Design: Retrospective immunohistochemical study.

Setting: Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, in a university hospital.

Conventional versus microdissection testicular sperm extraction for nonobstructive azoospermia.

Purpose: We established a practical and safe strategy for testicular sperm extraction (TESE) in patients with nonobstructive azoospermia and compared conventional with microdissection TESE.

Materials And Methods: In a retrospective comparative study 46 patients, including 22 with obstructive and 24 with nonobstructive azoospermia, underwent conventional TESE. Another 100 patients, including 26 with obstructive and 74 with nonobstructive azoospermia, underwent microdissection TESE.

Distribution of intracellular and extracellular expression of transforming growth factor-beta1 (TGF-beta1) in human testis and their association with spermatogenesis.

Aim: Spermatogenic dysfunction may result from thickening of seminiferous tubular basement membrane (BM) with tubular sclerosis. Transforming growth factor beta1 (TGF-beta1) plays an important role in fibrogenesis. The intracellular and extracellular expression of TGF-beta1 in the testis were immunohistochemically determined, using LC antibody (LC) for intracellular TGF-beta1 and CC antibody (CC) for extracellular TGF-beta1.