Publications by authors named "Takafumi Tozawa"
Article Synopsis
- TRIM family proteins form spherical structures called cytoplasmic bodies (CBs) to sequester excess TRIM molecules and potentially harmful substances.
- The study highlights that these CBs exist in a liquid droplet state due to liquid-liquid phase separation (LLPS) and contain various proteins, including ubiquitin.
- The assembly of TRIM32 into CBs is influenced by the activation of its E3 ligase activity, and similar regulatory mechanisms were observed for TRIM5α and TRIM63, linking ubiquitination to CB organization.
