Publications by authors named "Takafumi Okubo"
The mesothelium is a non-adhesive protective surface that lines the serosal cavities and organs within the body. The glycocalyx is a complex structure that coats the outer layer of the mesothelium. However, due to the limitations of conventional fixation techniques, studies on glycans are limited.
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- * The study investigates how galectin-3 behaves in the liver following acute injury caused by a synthetic substance, alpha-galactosylceramide, examining its expression levels over several days after injection.
- * Results showed that galectin-3 forms specific cell clusters in the liver during the early phase of injury, particularly noticeable on day 2, and its serum levels could serve as an important indicator for early diagnosis of acute liver damage.
Oxaliplatin, a platinum-based anticancer drug, is associated with peripheral neuropathy (oxaliplatin-induced peripheral neuropathy, OIPN), which can lead to worsening of quality of life and treatment interruption. The endothelial glycocalyx, a fragile carbohydrate-rich layer covering the luminal surface of endothelial cells, acts as an endothelial gatekeeper and has been suggested to protect nerves, astrocytes, and other cells from toxins and substances released from the capillary vessels. Mechanisms underlying OIPN and the role of the glycocalyx remain unclear.
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