Publications by authors named "Takabayashi K"
Upper gastrointestinal stenosis, which can be congenital or acquired, can lead to dysphagia. The association between trisomy 17p syndrome, a rare chromosomal abnormality, and upper gastrointestinal stenosis is unclear. A 20-year-old man diagnosed with trisomy 17p syndrome was referred to our department due to recurrent vomiting.
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- Previous trials suggest no overall benefit of screening for occult cancer in patients with venous thromboembolism (VTE), but high-risk patients may still benefit.
- A study involving 3,706 patients with acute VTE found that the incidence of newly diagnosed cancer increased over time, reaching 3.7% at one year and 7.0% at three years.
- Factors such as older age, a history of cancer, autoimmune disorders, past major bleeding, and lack of transient VTE risk factors were identified as independent predictors for new cancer diagnoses post-VTE.
Article Synopsis
- * Out of 1507 cancer patients studied, 4.7% experienced an ischemic stroke over a median follow-up of 1020 days, with a cumulative incidence of 4.0% at 1 year.
- * Key risk factors for stroke include specific cancers (pancreatic, ovarian, lung), dyslipidemia, metastasis, elevated D-dimer levels, and younger age, highlighting the need for vigilant monitoring in these patients.
This study included 52 Japanese older adults with Pittsburgh Sleep Quality Index (PSQI) scores > 5 and 52 healthy controls (HCs) with PSQI score ≤ 5. Diffusion-weighted imaging (DWI) and 3D T1-weighted imaging were acquired using 3T magnetic resonance imaging. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was calculated using preprocessed DWI.
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- Live swine are not ideal for training to manage intraoperative bleeding during endoscopic submucosal dissection (ESD) due to their coagulation issues.
- The study aimed to determine an effective heparin dosage for a bleeding model and to see how it affects bleeding during ESD procedures.
- Results showed that high doses of heparin led to significantly more intraoperative bleeding and hematomas in the heparinized model compared to a control group.
Vicious cycle of vitamin B insufficiency and heart failure in cardiology outpatients.
J Clin Biochem Nutr
November 2024
Heart failure is a major manifestation of vitamin B deficiency; beriberi. We have previously reported that even vitamin B insufficiency, milder than deficiency, is a risk for heart failure in the institutionalized elderly. Then in this cross-sectional study, sixty-eight cardiology outpatients were evaluated for their whole blood vitamin B and plasma brain natriuretic peptide (BNP) concentrations, a sensitive marker of heart failure, as well as their dietary intake.
View Article and Find Full Text PDFBackground: Modified double-layered suturing (Origami method; OGM), which can achieve robust closure even for large mucosal defects by folding the muscle layer using only through-the-scope clips. This study aimed to evaluate the feasibility of this OGM in duodenal ESD.
Methods: This retrospective observational study was conducted at a tertiary care hospital.
Article Synopsis
- Extracorporeal membrane oxygenation (ECMO) may be necessary for some patients with severe pulmonary embolism (PE), but its clinical outcomes are not well understood.
- *In a study analyzing data from 2035 patients with acute PE, 76 required ECMO, with findings indicating high rates of cardiac arrest (88.2%) at diagnosis and a 30-day death rate of 30.3%, all related to PE.
- *The research highlighted significant complication rates, including a 54% incidence of major bleeding, suggesting the need for improved management strategies and future clinical trials.
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- Endoscopic submucosal dissection including papilla (ESDIP) was developed to improve outcomes for patients with duodenal tumors, addressing issues like lesion size and local recurrence that are common with endoscopic papillectomy (EP).
- A study of 54 patients from 2010 to 2024 showed that ESDIP had a high success rate, with 96% of resections completed and a low overall recurrence rate of 15% after one year.
- While some complications occurred, such as intraprocedural perforation and delayed bleeding, the approach remains a promising low-invasive alternative to more extensive surgeries like pancreaticoduodenectomy.
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- The study investigates the link between duodenal epithelial tumors (DETs) and colorectal tumors, addressing a controversial topic in familial colorectal adenomatous polyposis.
- Conducted over four years, the research compared 163 patients with DETs to 177 individuals undergoing routine colonoscopy, finding a significantly higher adenoma detection rate (ADR) in the DET group (63.2% vs 23.6%).
- The results indicated that DETs are associated with a five-fold increase in adenoma detection and a six-fold increase in advanced neoplasia detection, suggesting the need for screening colonoscopy in DET patients.
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- Elevated white blood cell (WBC) counts are identified as a risk factor for adverse outcomes in patients with venous thromboembolism (VTE) who do not have active cancer.
- In a study involving 5,197 patients, those with the highest WBC counts (Q4) were more likely to experience severe forms of VTE like pulmonary embolism and had a significantly higher risk of death and major bleeding over five years.
- The findings suggest that monitoring WBC counts at VTE diagnosis can help in assessing patient risk and potential outcomes.
Article Synopsis
- * The COMMAND VTE Registry-2 study tracked 5,197 patients with venous thromboembolism in Japan, finding that 2.3% of those with acute PE developed CTEPH over an average follow-up of 747 days.
- * Identified risk factors for developing CTEPH included being female, longer time from symptom onset to PE diagnosis, experiencing hypoxemia, having right heart load, lower D-dimer levels, and having
Postoperative maxillary cysts (POMCs) present significant challenges, especially when located laterally or when the infraorbital nerve's course is unclear on imaging. Traditional endoscopic approaches are often limited by a high risk of recurrence and potential nerve injury. Here, we report a case of a 72-year-old woman with a right maxillary cyst, which caused pain and swelling.
View Article and Find Full Text PDFInhaled beta-2 adrenoceptor agonists (iβ2A) are routinely used as bronchodilators in the treatment of asthma. However, their cardiac effects in athletes are scarcely examined. Thus, the aim of this study was to evaluate the effects of iβ2A on left ventricular (LV) systolic function (SF) by echocardiography in healthy, non-asthmatic female and male endurance athletes.
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- The simplified Pulmonary Embolism Severity Index (sPESI) score helps identify low-risk patients for home treatment of pulmonary embolism, but its use with direct oral anticoagulants hasn't been thoroughly studied.
- A study of 2,496 patients with stable pulmonary embolism found that only 25% had an sPESI score of 0, and among those, only 17% were treated at home, though their 30-day mortality was notably low (0% vs. 4.8% in higher risk groups).
- Factors promoting home treatment included the absence of temporary risk factors, no elevated cardiac biomarkers, and the use of direct oral anticoagulants during the acute phase.
Article Synopsis
- * A study compared 50 poor sleepers and 50 good sleepers, revealing that poor sleepers had significantly lower myelin volume in key brain regions, which correlated with decreased cognitive function and increased depression.
- * The findings suggest that circadian clock gene expression plays a role in these differences, with certain genes linked to regional variations in myelin content and overall brain health in relation to sleep quality.
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- The study investigates the safety and effectiveness of endoscopic submucosal dissection (ESD) for colorectal and gastric cancers, focusing on predicting resectability using endoscopic ultrasound (EUS).
- EUS classifications for tumors were established, determining how visible the submucosal layer was, and the findings showed a significant correlation with the pathological results following ESD.
- The results indicated that EUS could be crucial in predicting which tumors are likely to be successfully resected, with higher success rates observed in Type I tumors compared to Type II and III.
The incidence of duodenal tumors (DTs) is increasing. However, the mechanisms underlying its development remain unclear. Environmental factors, including the microbiome and bile acids (BAs), are believed to influence tumor development.
View Article and Find Full Text PDFPurpose: No definitive procedures have been proposed for orbital floor fractures extending to the slope of the posterior end, which is a challenging problem. This study demonstrates the effectiveness of an orbital reconstruction procedure based on anatomical landmarks that we developed, called the three landmarks procedure (TLP).
Methods: This study is a single-center retrospective cohort study conducted by the Department of Otorhinolaryngology, Japanese Red Cross Asahikawa Hospital.
Article Synopsis
- A study in Japan compared outcomes of patients with venous thromboembolism (VTE) treated with warfarin (2010-2014) versus direct oral anticoagulants (DOACs) (2015-2020) from two multicenter registries.
- The use of DOACs skyrocketed from 2.6% in the warfarin era to 79% in the DOAC era, leading to a significant reduction in the 5-year recurrence rate of VTE (10.5% to 9.5%).
- However, the incidence of major bleeding remained similar between the two eras, indicating that while DOACs may reduce VTE recurrence, concerns about bleeding risks continue.
Background: Initial hemodynamic status in patients with acute pulmonary embolism (PE) concerns their acute clinical outcomes. Nevertheless, the characteristics of initial hemodynamic dysfunction and acute mortality in PE patients with active cancer is still controversial.
Methods: We analyzed the data of 1715 PE patients in the COMMAND VTE Registry to compare initial hemodynamic dysfunction, management strategies, and mortality outcomes at 30 days after PE diagnosis between patients with and without active cancer (N = 393 and N = 1322).
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- The Water Pressure Method (WPM) in colorectal endoscopic submucosal dissection (ESD) has advantages but faces challenges like excess water injection and field contamination.
- A study evaluated a new continuous liquid-suction catheter attachment (CLCA) to improve ESD outcomes using WPM, analyzing 31 cases from August 2022 to September 2023.
- Results showed all lesions were successfully removed without perforation, with effective volume measurements for injection and suction, indicating that the novel system helps maintain a clear operative field during the procedure.
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- A new deep learning-based method for brain segmentation (DLHBS) has been developed to accurately segment T1-weighted MRI scans into 107 brain subregions and calculate their volumes.
- The method was trained on data from 486 subjects and tested for consistency in volume measurements using scans from 11 healthy subjects across three MRI scanners.
- Results indicated that DLHBS outperformed traditional segmentation tools like SPM and FreeSurfer in terms of both repeatability and reproducibility for multiple brain regions.
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- The PE-SARD bleeding score was developed to predict early major bleeding in patients with pulmonary embolism (PE) but has not been fully validated externally.
- A study using data from the COMMAND VTE Registry involving 2,781 acute PE patients categorized them into high, intermediate, and low-risk groups based on this score, revealing a clear increase in bleeding rates with higher risk scores.
- The results indicated the score has modest effectiveness in predicting bleeding risk overall, with better performance in patients without active cancer.