Visualizing Intramolecular Dynamics of Membrane Proteins.

Membrane proteins play important roles in biological functions, with accompanying allosteric structure changes. Understanding intramolecular dynamics helps elucidate catalytic mechanisms and develop new drugs. In contrast to the various technologies for structural analysis, methods for analyzing intramolecular dynamics are limited.

High Expression of , and Predicts a Poor Prognosis in Late-stage Breast Cancer.

Background/aim: Co-expression of c-Met and ALDH1A3 indicates a poor prognosis in stage III-IV breast cancers and contributes to cell proliferation and tumor formation by ALDH1-positive breast CSCs. PKCλ is overexpressed and contributes to a poor prognosis in several cancers.

Materials And Methods: A breast cancer genomics data set (METABRIC, n=2509) was downloaded and analyzed, as was the effect c-Met and PKCλ inhibitors on ALDH1 cell viability and tumor-sphere formation.

Fabrication of Fluorite-Type Fluoride BaBiF Thin Films by Fluorination of Perovskite BaBiO Precursors with Poly(vinylidene fluoride).

Metal fluorides are gathering significant interest for use in many applications, such as optical glasses, chemical sensors, and solid electrolytes using fluoride ion batteries, due to their high transparency over a wide wavelength range (ultraviolet to infrared) and fast fluoride ion conductivity. Here, we present a topotactic route for synthesizing thin films of fluorite-type BaBiF (BBF), a promising fluoride ion conductor, from perovskite-type BaBiO (BBO) precursor films by fluorination using poly(vinylidene fluoride). The fluorination reaction fully converted BBO to BBF without stopping at the oxyfluoride stage.