In vitro cyclooxygenase inhibition assay for evaluating ecotoxicity of the surface water and domestic wastewater in the Tone Canal, Japan.

Cyclooxygenase (COX) plays an important role in eicosanoid metabolism. Nonsteroidal anti-inflammatory drugs (NSAIDs) function as COX inhibitors and are frequently detected in the aquatic environment. Here, we measured the in vitro COX-inhibiting activity of the surface water and domestic wastewater in the Tone Canal, Japan.