Publications by authors named "Takaaki Kogo"
Article Synopsis
- In April 2020, new guidelines by the Japanese Circulation Society recommended shorter dual antiplatelet therapy (DAPT) for high bleeding risk patients, prompting a study in June 2020 involving 1,136 patients who had undergone percutaneous coronary intervention (PCI).
- The study found that 55.2% of patients received planned short DAPT (less than 3 months), resulting in a significantly shorter average DAPT duration compared to those on standard therapy, but similar rates of major adverse cardiovascular events and bleeding complications across both groups.
- Key factors predicting adverse events included age 75 or older, certain health conditions like severe chronic kidney disease, and low hemoglobin levels, indicating that despite the shorter therapy,
The main cause of acute coronary syndrome (ACS) is plaque rupture and thrombus formation. However, it has not been fairly successful to identify vulnerable plaque to rupture using conventional parameters of intravascular imaging modalities. Fractal analysis is one of the mathematical models to examine geometrical features of picture image using a specific parameter called as fractal dimension (FD) which suggests geometric complexity of the image.
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- The study investigates the relationship between the geometry of ruptured coronary plaques and the occurrence of acute coronary syndrome (ACS) using advanced computational fluid dynamics (CFD) in patients with coronary artery disease.
- It involved 45 patients where three-dimensional intravascular ultrasound (IVUS) images were analyzed to compare blood flow profiles around ruptured plaques in those with provoked ACS versus those without.
- Results indicated that blood flow was more stagnant around plaques that caused ACS compared to silent ruptures, suggesting that differing flow characteristics may contribute to the risk of ACS.
Background And Aims: Macrophage accumulation in arteriosclerotic plaque of coronary arteries is involved in plaque destabilization. Atherosclerosis has been known to be progressive in patients with type 2 diabetes mellitus (DM). This study compared the features of 3-dimensional (3D) spatial distribution of macrophage accumulation within coronary artery wall between acute coronary syndrome (ACS) patients with DM (n = 20) and those without (non-DM, n = 20) by using intravascular ultrasound (IVUS) and optical coherence tomography (OCT).
View Article and Find Full Text PDFBackground: Coronary artery vasospasm (CS) can be identified as either a diffuse type or focal type; however, the difference in endothelial characteristics between these spasm types remains unclear. The features of coronary intima associated with diffuse spasm and focal spasm using coronary angioscopy (CAS) were evaluated and the optical coherence tomography (OCT) findings were compared.
Methods: CAS and/or OCT observational analysis was performed in 55 patients (mean age: 61.
Vascular endothelial dysfunction plays an important role in the process of atherosclerosis up to the final stage of plaque rupture. Vascular endothelial dysfunction is reversible, and can be recovered by medications and life-style changes. Improvement in endothelial function may reduce cardiovascular events and improve long-term prognosis.
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