Poor Motor-Function Recovery after Spinal Cord Injury in Anxiety-Model Mice with Phospholipase C-Related Catalytically Inactive Protein Type 1 Knockout.

Mice with a knockout of phospholipase C (PLC)-related inactive protein type 1 (PRIP1 mice) display anxiety-like behavior and altered γ-aminobutyric acid (GABA)-receptor pharmacology. Here, we examined associations between anxiety and motor-function recovery in PRIP1 mice after a spinal cord injury (SCI) induced by a moderate contusion injury at the 10th thoracic level. Uninjured PRIP1 mice showed less distance than wild-type (WT) mice in the center 25% in an open field test (OFT), indicating anxiety-like behavior.