Synthesis and molecular docking analysis of MBH adducts' derived amides as potential inhibitors.

Humans suffer from various diseases that require more specific drugs to target them. Among the different potent agents, s serve as good antibacterial agents; however, s are resistant to such antibiotics. The present study was designed to prepare efficient inhibitor amides (12-15) from inexpensive, easily accessible, and bioactive precursors; Morita Baylis Hillman (MBH) adducts (5-8).

Development and Validation of Novel HPLC Methods for Quantitative Determination of Vitamin D3 in Tablet Dosage Form.

In the present work, an efficient isocratic HPLC method was developed for the precise and accurate estimation of vitamin D in tablet form. The chromatographic conditions comprised an L3 silica column (5 µm in particle size, 4.6 mm × 250 mm) with a mobile phase n-hexane/ethyl acetate (85:15 /) with a flow rate of 2.

Green synthesis, characterization, and antibacterial activity of silver nanoparticles using stem extract of Zanthoxylum armatum.

In this study, we report the green synthesis of silver nanoparticles (AgNPs) using Zanthoxylum armatum stem extract. The characteristic absorption at 385 nm suggested synthesis of AgNPs which was further confirmed by SEM, with a size in the range of 46.66 nm to 60.

Green synthesis, characterization, antibacterial activity of metal nanoparticles and composite oxides using leaves extract of Ocimum basilicum L.

Nanoparticles plays a key role in the development of novel antibacterial substances against various pathogenic microorganisms. These nanoparticles due to their smaller size could be very effective as they can improve the antibacterial activity through lysis of bacterial cell wall. In the present research work, ZnO, MgO, NiO, AlO nanoparticles, and MgNiO, and AlZnO composite oxides were synthesized by green method from Ocimum basilicum leaves extract.

The Effect of AlI Nanoadditive on the Thermal Behavior of PMMA Subjected to Thermoanalytical Py-GC-MS Technique.

Thermal degradation of polymethylmethacrylate (PMMA) was studied by using inorganic salt of aluminum triiodide (AlI). The composites of PMMA were prepared with AlI by changing the concentration of the AlI additive from 2% to 10% (/). The PMMA composites with AlI were characterized by TGA, DTG, SEM, FTIR, HBT, and Py-GC-MS techniques.

Phytochemical screening, green synthesis of gold nanoparticles, and antibacterial activity using seeds extract of Ricinus communis L.

In the current research study, the phytochemical tests of the Ricinus communis L methanolic extract detected the presence of coumarin, reducing sugar, emodines, terpenoids, flavonoids, and steroids while water extract showed the presence of alkaloids, terpenoids, steroids, and soluble starch. The methanolic extract was further subjected to synthesize Au nanoparticles. The synthesized nanoparticles were confirmed by UV-Vis through the appearance of a peak at 550 nm which correspond to the existence of Au nanoparticles.

Density functional theory, molecular docking and bioassay studies on ()-2-hydroxy-N-(2,3,4,)-1,3,4 trihydroxyicos-16-en-2-yl)tricosanamide.

A novel indigoferamide-A, earlier isolated from the seeds of Wall was characterized using density functional theory, molecular docking and bioassays studies. Density functional theory calculations were performed at B3LYP/6-31G(d,p) to gain geometric insight of the compound. Conformational analyses have been performed around three important dihedral angles to explore the lowest energy structure and conformer.

Spectroscopic and density functional theory studies of 7-hydroxy-3'-methoxyisoflavone: A new isoflavone from the seeds of Indigofera heterantha (Wall).

A new isoflavone 7-hydroxy 3'-methoxyisoflavone (1) is isolated from the seeds of Indigofera heterantha. The structure of this new compound was established using spectroscopic techniques such as ID, 2D NMR, and mass spectrometry. Density functional theory calculations are carried out for the first time for geometric, electronic and spectroscopic properties of 1 (isoflavone).

Isolation, spectroscopic and density functional theory studies of 7-(4-methoxyphenyl)-9H-furo[2,3-f]chromen-9-one: a new flavonoid from the bark of Millettia ovalifolia.

The phytochemical examination of chloroform soluble fraction (FX2) of methanolic extract of bark of Millettia ovalifolia yielded a new flavonoid; 7-(4-methoxyphenyl)-9H-furo [2,3-f]chromen-9-one (1). Compound 1 is characterized by spectroscopic analytical techniques such as UV, IR, 1D, 2D NMR spectroscopy, and mass spectrometry. A theoretical model is also developed for obtaining geometric, electronic and spectroscopic properties of 1.

Genotyping of HCV RNA reveals that 3a is the most prevalent genotype in mardan, pakistan.

The clinical outcomes of patients infected with hepatitis C virus (HCV) range from acute resolving hepatitis to chronic liver diseases such as liver cirrhosis or hepatocellular carcinoma. Identification of the infecting virus genotype is indispensable for the exploration of many aspects of HCV infection, including epidemiology, pathogenesis, and response to antiviral therapy. 1419 individuals were screened for anti-HCV in this study, of which 166 (11.