Publications by authors named "Taizo Sugimoto"
Objective: Adiponectin (APN) improves insulin resistance and prevents atherosclerosis, and HDL removes cholesterol from atherosclerotic lesions. We have demonstrated that serum HDL-cholesterol (HDL-C) and APN concentrations are positively correlated and that APN accelerates reverse cholesterol transport (RCT) by increasing HDL synthesis in the liver and cholesterol efflux from macrophages. We previously reported that APN reduced apolipoprotein (apo) B secretion from the liver.
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- Postprandial hyperlipidemia involves the buildup of chylomicrons and their remnants after eating, which may be linked to cardiovascular diseases, though research is ongoing.
- A study enrolled 189 patients undergoing coronary angiography to investigate the relationship between chylomicron remnants and coronary artery disease (CAD), focusing on biochemical markers of lipid metabolism.
- Results showed that fasting serum apo B-48 levels were significantly higher in CAD patients compared to non-CAD subjects, indicating that elevated apo B-48, especially when combined with other risk factors, is associated with a higher prevalence of CAD.
Article Synopsis
- The study investigates postprandial hyperlipidemia (PH), focusing on how impaired metabolism of triglyceride-rich lipoproteins impacts lipid levels after high-fat or standard meals, aiming to find simpler markers for PH without using time-consuming tests.* -
- Ten healthy male subjects were given high-fat and standard meals, and their lipid and apolipoprotein levels were measured, revealing significantly higher triglyceride and apo B-48 levels after the high-fat meal compared to the standard meal.* -
- The findings suggest that the postprandial triglyceride increase is primarily linked to chylomicrons and their remnants, with fasting apo B-48 levels strongly predicting this increase, indicating it could serve as an easy marker for
Background: Postprandial hyperlipidemia (PPHL) is an independent risk factor for coronary heart disease (CHD) which is based on the accumulation of chylomicrons (CM) and CM remnants containing apolipoprotein B-48 (apoB-48). Since atherosclerotic cardiovascular diseases are frequently observed even in subjects with normal serum triglyceride (TG) level, the correlation between fasting apoB-48 containing lipoproteins and carotid intima-media thickness (IMT) was analyzed in subjects with normal TG levels.
Methods: From subjects who took their annual health check at the Osaka Police Hospital (n=245, male), one-hundred and sixty-four male subjects were selected to take part in this study; the excluding factors were: systolic blood pressure ≥ 140 mmHg, intake of antihypertensive or antihyperlipidemic drugs, or age >65 years.
Background/aims: To elucidate the role of microsomal triglyceride transfer protein (MTP) in the pathogenesis of alcoholic fatty liver, the effects of ethanol on MTP activity and gene expression were investigated.
Methods And Results: Male Sprague-Dawley rats fed an ethanol-containing liquid diet for 37 days, respectively, showed 2.9- and 4.