Publications by authors named "Taito Shiozawa"
Serotonin(1A) receptor-mediated synaptic response in the rat medial prefrontal cortex is altered by early life stress: in vivo and in vitro electrophysiological studies.
Nihon Shinkei Seishin Yakurigaku Zasshi
February 2011
Article Synopsis
- Serotonin (5-HT)(1A) receptors are important for understanding fear memory mechanisms, particularly influenced by early-life stress experiences.
- The study found that rats exposed to footshock stress during different postnatal weeks exhibited distinct responses, indicating that stress timing affects 5-HT(1A) receptor function in the medial prefrontal cortex (mPFC).
- Results showed that while a specific serotonin agonist decreased evoked potentials in normal and later-stressed groups, it increased potentials in earlier stressed rats, suggesting that early stress leads to lasting functional changes in fear-related neuronal connectivity.