Perioperative changes in coagulation and platelet contribution to clot strength after transcatheter aortic valve implantation: A study using thromboelastography and conventional markers.

Introduction: Thrombotic and haemorrhagic complications have been reported following transcatheter aortic valve implantation (TAVI). However, few reports have studied perioperative changes in coagulation and platelet function after TAVI. Furthermore, there are no clear guidelines for antithrombotic therapy.

Machine learning-based causal models for predicting the response of individual patients to dexamethasone treatment as prophylactic antiemetic.

Risk-based strategies are widely used for decision making in the prophylaxis of postoperative nausea and vomiting (PONV), a major complication of general anesthesia. However, whether risk is associated with individual treatment effect remains uncertain. Here, we used machine learning-based algorithms for estimating the conditional average treatment effect (CATE) (double machine learning [DML], doubly robust [DR] learner, forest DML, and generalized random forest) to predict the treatment response heterogeneity of dexamethasone, the first choice for prophylactic antiemetics.