Publications by authors named "Taisuke Enokida"
Unlabelled: causes a variety of human infections, and hospital outbreaks with this pathogen have also been reported. The purpose of this study is to describe the clinical characteristics of an outbreak of involving 15 patients and four healthcare workers (HCWs), as well as the molecular characteristics of the causative isolates. The course and response to the outbreak were reviewed, and information on the characteristics of the patients was extracted retrospectively from the medical records.
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- Secondary osteomyelitis pubis is rare, particularly after surgeries for vulvar cancer, and can be difficult to diagnose and treat.
- The study discusses two elderly patients who developed this condition following surgical site infections from vulvectomy and reconstructive surgery.
- Diagnosis was confirmed via CT and MRI, leading to successful treatment with debridement and targeted antimicrobial therapy, resulting in pain relief and no relapse after several months.
Although piperacillin-tazobactam (TZP) was shown to be less effective than carbapenems in treating bacteremia due to extended-spectrum β-lactamase-producing (ESBL)-producing organisms in a randomized controlled trial, the fact that many of the causative organisms co-produced inhibitor-resistant OXA-1 along with ESBLs may have influenced the results. In this study, we compared the therapeutic effectiveness of TZP and carbapenem in treating ESBL-producing Escherichia coli bacteremia in areas with low frequency of OXA-1 co-production. Forty patients, 14 in the TZP treatment group and 26 in the carbapenem treatment group, were included in the analysis.
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- The study aimed to identify risk factors for Pneumocystis jirovecii pneumonia (PCP) in patients with solid tumors, beyond just high-dose corticosteroid use.
- Researchers reviewed the medical records of patients with solid tumors diagnosed with PCP from 2006 to 2018 in Tokyo, finding that lung and breast cancers were the most common underlying conditions.
- Results showed that many patients were not on high-dose corticosteroids, and other factors such as lung diseases, recent chemotherapy, and radiation therapy likely contributed to the development of PCP, with a significant mortality rate of 40%.
Sodium 4-phenylbutyrate (PB) is an orphan drug for the treatment of urea cycle disorders. It also inhibits the development of endoplasmic reticulum stress, the action of histone deacetylases and as a regulator of the hepatocanalicular transporter. PB is generally considered to have the potential for use in the treatment of the diseases such as cancer, neurodegenerative diseases and metabolic diseases.
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- Sodium 4-phenylbutyrate (PB) is a drug primarily used for treating urea cycle disorders but shows potential for other therapeutic uses.
- Research analyzed how PB binds to albumin from different species—human, bovine, rabbit, and rat—to better understand its efficacy and safety in preclinical testing.
- The study found that PB mainly binds to one high-affinity site on albumin, with varying affinities across species, influenced by structural differences in the PB-binding sites.
Sodium 4-phenylbutyrate (PB) has many pharmacological activities; therefore extending its clinical use to the treatment of a wider variety of diseases would be desirable. However, our knowledge of the binding of PB to plasma proteins is not extensive. To address this issue in more detail, we characterized the protein binding of PB.
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