IgDIgM B Cells in Common Variable Immunodeficiency.

Common variable immunodeficiency (CVID) is the most frequent form of primary hypogammaglobulinemia in adults. In addition to recurrent infections and respiratory manifestations, CVID patients may present several non-infection complications such as autoimmune diseases. The mechanisms that lead to immune dysregulation in CVID are not completely understood.

Major depression favors the expansion of Th17-like cells and decrease the proportion of CD39Treg cell subsets in response to myelin antigen in multiple sclerosis patients.

Background: Mood disorders have been associated with risk of clinical relapses in multiple sclerosis (MS), a demyelinating disease mediated by myelin-specific T cells.

Objectives: We aimed to investigate the impact of major depressive disorder (MDD) and cytokine profile of T-cells in relapsing remitting MS patients.

Methods: For our study, plasma and PBMC were obtained from 60 MS patients (30 with lifetime MDD) in remission phase.

Phenotypic analysis of T follicular helper and T follicular regulatory cells in primary selective IgM deficiency.

Selective IgM deficiency (SIgMD) is a rare immunodeficiency characterized by serum IgM below two standard of mean, and normal IgG and IgA levels. Both in human and mice with selective IgM deficiency, germinal centers cells are decreased. The development of germinal center and humoral immunity are regulated in part by follicular helper T (T) and follicular regulatory T (T) cells.

Phenotypic and Functional Analysis of T Follicular Cells in Common Variable Immunodeficiency.

Introduction: One of the most frequent abnormalities of B cells in common variable immunodeficiency (CVID) is reduced number of class-switched memory B cells, suggesting an impaired germinal center response. Therefore, due to its pivotal role in regulating the development of humoral immunity, the objective of this study was to evaluate the role of circulating T follicular helper (cTFH) and circulating T follicular regulatory (cTFR) cells in the pathogenesis of CVID.

Methods: cTFH and cTFR cells from CVID patients and healthy subjects were phenotypically characterized by flow cytometry.