Publications by authors named "Taison Endoh"
Article Synopsis
- - The study investigates whether eicosapentaenoic acid (EPA) can reduce artery contractions caused by substances like thromboxane mimetics (U46619) and prostaglandin F (PGF), specifically by targeting the prostanoid TP receptor.
- - Results show that EPA effectively inhibited contractions in porcine basilar and coronary arteries in a dose-dependent way but had no impact on contractions triggered by high potassium levels (KCl).
- - Additionally, EPA reduced calcium signaling related to the TP receptor in human cells but only had minimal effects related to the FP receptor, suggesting that the inhibition of TP receptors is a key mechanism for EPA's ability to relax these artery contractions.
Docosahexaenoic acid (DHA, an n-3 polyunsaturated fatty acid) inhibits U46619 (a TP receptor agonist)- and prostaglandin F-induced contractions in rat aorta and mesenteric arteries. However, whether these effects could be replicated in vasospasm-prone vessels, such as coronary and cerebral arteries, remains unknown. Here, we evaluated the changes in pig coronary and basilar artery tensions and intracellular Ca concentrations in human prostanoid TP or FP receptor-expressing cells.
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