Publications by authors named "Tairin Uchino"

Background: The long-term risk of pouch failure after restorative proctocolectomy with ileal-pouch anal anastomosis (IPAA) range from 5% to 15%. Salvage surgery for failing IPAA may be achieved by disconnecting the IPAA and either repairing and reusing the existing pouch (REP) or constructing a neopouch (NEO). We aimed to evaluate whether there are differences in long-term functional pouch survival and functional outcomes between the REP group and the NEO group.

View Article and Find Full Text PDF

Background: A colosplenic fistula (CsF) is an extremely rare complication. Its diagnosis and management remain poorly understood, owing to its infrequent incidence. Our objective was to systematically review the etiology, clinical features, diagnosis, management, and prognosis to help clinicians gain a better understanding of this unusual complication and provide aid if it is to be encountered.

View Article and Find Full Text PDF

Background: Ileal pouch-anal anastomosis is a technically demanding procedure with many potential complications. Rediversion with an ileostomy is often the first step in pouch salvage; however, it may not be clear if an individual patient will undergo subsequent pouch salvage surgery. We aimed to describe the indications and short- and long-term outcomes of rediversion in our pouch registry.

View Article and Find Full Text PDF

Background: The mesentery has recently been implicated in the pathophysiology of Crohn's disease (CD), and several techniques have been developed to target the mesentery to reduce its influence on recurrence. We aimed to describe short-term safety and feasibility after these approaches.

Methods: This is a comparative, retrospective, single-center cohort study of consecutive CD patients undergoing primary or redo ileocolic resection from 2015 to 2022 with Kono-S anastomosis (KSA), extended mesenteric excision (EME) only, or both: mesenteric excision and exclusion (MEE).

View Article and Find Full Text PDF
Article Synopsis
  • - The study examined the effectiveness of fundus-first laparoscopic cholecystectomy (FFLC) as a surgical option for severe cholecystitis by comparing outcomes from two groups of patients: one before and one after FFLC became common practice.
  • - Results showed that after FFLC was introduced, there was a significant increase in its usage, a decrease in laparoscopic subtotal cholecystectomy cases, fewer instances of bile duct complications, and a shorter average hospitalization time for patients.
  • - Overall, the findings suggest that FFLC leads to better surgical outcomes for patients with severe cholecystitis, demonstrating its value as an effective surgical technique.
View Article and Find Full Text PDF

Background: The criteria for deciding upon non-operative management for nonocclusive mesenteric ischemia (NOMI) are poorly defined. The aim of this study is to determine the prognostic factors for survival in conservative treatment of NOMI.

Methods: Patients with bowel ischemia were identified by searching for "ICD-10 code K550" in the Diagnosis Procedure Combination database between June 2015 and May 2020.

View Article and Find Full Text PDF
Article Synopsis
  • The da Vinci Surgical System (DVSS) is becoming more popular for general surgeries, including inguinal hernia repairs, particularly in the USA, with over 5500 systems installed globally.
  • While studies suggest robotic surgery is safe and feasible for hernia repair, there is no strong evidence proving it is superior to traditional open or laparoscopic methods in terms of long-term outcomes.
  • Robotic surgery may offer advantages like reduced complications, less postoperative pain, and a quicker learning curve for surgeons, but its implementation remains limited in many countries.
View Article and Find Full Text PDF

A 55-year-old man underwent Hartmann's procedure for generalized peritonitis caused by perforation of sigmoid colon cancer, which was histologically diagnosed as tubular adenocarcinoma penetrating the muscularis propria (T3). The extent of lymph node dissection was insufficient for the advanced cancer, according to the concept of complete mesocolic excision. Two months after surgery, he underwent laparoscopic Hartmann's reversal, combined with interval lymphadenectomy.

View Article and Find Full Text PDF

Aim: Robotic surgery using the da Vinci system has markedly increased worldwide. However, robotic inguinal hernia repair remains unpopular outside the United States. We introduced and evaluated a robotic transabdominal preperitoneal repair (R-TAPP) technique for inguinal hernia in our hospital.

View Article and Find Full Text PDF

Background: Detection of common bile duct (CBD) stones is a major objective of intraoperative cholangiography (IOC) in laparoscopic cholecystectomy (LC). We evaluated the feasibility and safety of the routine use of transcystic choledochoscopy following IOC (dual common bile duct examination: DCBDE), which may improve the diagnostic accuracy of CBD stones and facilitate one-stage clearance, in LC for suspected choledocholithiasis.

Methods: Between May 2017 and November 2018, 38 patients with suspected choledocholithiasis were prospectively enrolled in this study, regardless of whether they underwent endoscopic sphincterotomy.

View Article and Find Full Text PDF

Purpose: The aim of this study was to investigate the predictive relevance of tumor sidedness on surgical resection after recurrence by evaluating the treatment outcomes after primary resection and recurrence in patients with localized colon cancer (CC).

Methods: A total of 735 consecutive patients who underwent curative resection for Stage I-III CC from 1997 to 2013 were categorized as having either right- or left-sided CC, and survival after primary surgery and after recurrence were analyzed.

Results: A total of 104 patients (14.

View Article and Find Full Text PDF

Background: Based on the spatial relationship of an aberrant right hepatic duct (ARHD) with the cystic duct and gallbladder neck, we propose a practical classification to evaluate the specific form predisposing to injury in laparoscopic cholecystectomy (LC).

Methods: We retrospectively investigated the preoperative images (mostly magnetic resonance cholangiopancreatography) and clinical outcomes of 721 consecutive patients who underwent LC at our institute from 2015 to 2018. We defined the high-risk ARHD as follows: Type A: communicating with the cystic duct and Type B: running along the gallbladder neck or adjacent to the infundibulum (the minimal distance from the ARHD < 5 mm), regardless of the confluence pattern in the biliary tree.

View Article and Find Full Text PDF

We report a case of ileal conduit necrosis after total pelvic exenteration for recurrence of gastrointestinal stromal tumor. A 47-year-old man was diagnosed with recurrence of gastrointestinal stromal tumor adjacent to the prostate after abdominoperineal resection 10 years prior. With imatinib administration for 18 months, the local recurrence decreased in size but did not separate from the prostate.

View Article and Find Full Text PDF
Article Synopsis
  • This study assessed the outcomes of 26 patients with stage IV colorectal cancer who had synchronous peritoneal metastases after complete surgical removal (R0 status).
  • The patients' peritoneal lesions were categorized based on the presence of cancer cells and the size/type of the tumors to analyze their impact on survival rates.
  • Findings indicated that those with massive type metastatic tumors had better disease-free and overall survival compared to those with diffuse type tumors, highlighting the importance of detailed pathological analysis for prognosis.
View Article and Find Full Text PDF
Article Synopsis
  • A 77-year-old man was treated for cecal cancer with lung and liver metastases using a combination of chemotherapy and surgery, showing initial success with tumor reduction and no new metastatic lesions.
  • After several surgeries, including tumor resections in different locations and a decline in tumor markers, a new mass was discovered near a mesh-plug prosthesis, indicating potential metastasis.
  • The case highlights the risk of malignant tumor metastases at surgical sites, particularly in patients with advanced cancer, emphasizing the need for careful monitoring of patients with similar histories for signs of recurrence around surgical implants.
View Article and Find Full Text PDF

Herein, we describe the operative procedure for combined resection of re-recurrent lateral lymph nodes and the external iliac vein. There is no consensus on the clinical implications of resection of locally re-recurrent colorectal tumors, as the operative procedure is extremely difficult. We present the case of a 52-year-old woman who underwent abdominoperineal resection.

View Article and Find Full Text PDF
Article Synopsis
  • A 78-year-old woman with T1 rectal cancer initially underwent transanal excision (TAE) in December 2006, with the cancer classified as stage I.
  • After 10 years of follow-up without additional treatment, she returned with symptoms of melena and was diagnosed with recurrent rectal cancer in November 2016.
  • Following a laparoscopic abdominoperineal resection, the recurrence was classified as stage IIIB, highlighting the importance of long-term follow-up for detecting late local recurrences, particularly in high-risk patients.
View Article and Find Full Text PDF

Introduction: Laparoscopic subtotal cholecystectomy (LSC) has been recognized as an alternative to conversion to laparotomy for severe cholecystitis. However, it may be associated with an increased risk of recurrent stones in the gallbladder remnant. The objective of this study was to evaluate the safety and feasibility of the complete removal of the gallbladder cavity in LSC for severe cholecystitis using the cystic duct orifice suturing (CDOS) technique.

View Article and Find Full Text PDF
Article Synopsis
  • - CBP-93872 blocks the DNA damage response by interfering with the ATM-ATR signaling pathway, hindering the cell's ability to pause the cell cycle in G2 phase after DNA breaks.
  • - In studies with colorectal and pancreatic cancer cell lines, combining CBP-93872 with platinum-based drugs (like oxaliplatin and cisplatin) and pyrimidine antimetabolites (like gemcitabine and 5-FU) enhanced the effectiveness of these treatments.
  • - The research indicates that CBP-93872 boosts the sensitivity of cancer cells to chemotherapy by preventing the activation of certain checkpoints, leading to increased cell death from these treatments.
View Article and Find Full Text PDF

A 73-year-old man underwent abdominoperineal resection for a rectal cancer. He developed a hip pain 3 years and 6 months after the surgery. A CT scan revealed a local recurrence in the perineum and multiple lung metastases in the bilateral lung.

View Article and Find Full Text PDF

We report 4 cases of gastrointestinal perforation associated with systemic administration of bevacizumab. Case 1: A 51- year-old man with colorectal cancer (CRC) received mFOLFOX+bevacizumab (Bev). A small intestinal perforation occurred 7 days after Bev administration (Bev-a) and was successfully treated with omental packing.

View Article and Find Full Text PDF