Publications by authors named "Taine de Bastos Brum"
Article Synopsis
- A new bilayer film made from gellan gum and pullulan was developed to deliver silibinin for treating atopic dermatitis.
- This film showed improved adhesion, a more effective release of silibinin, and better protective properties for the skin compared to traditional treatments.
- The study found that the nano-based film significantly reduced inflammation and oxidative damage in mice, suggesting it may be a promising alternative for managing atopic dermatitis.
Article Synopsis
- This study focused on creating gellan gum films that incorporate silibinin-loaded nanocapsules for topical application, aiming to enhance the delivery of this flavonoid to the skin.
- The nanocapsules were found to be around 140 nm in size, with nearly 100% efficiency in encapsulating silibinin, and their conversion into films resulted in transparent, flexible materials that retained good moisture absorption.
- The nano-based films demonstrated better distribution and prolonged release of silibinin compared to standard films, showed improved stability, and did not cause irritation, making them a promising option for skin delivery.
This study aimed to characterize the physicochemical properties of 3,3'-diindolylmethane (DIM)-loaded nanocapsules (NCs) as well as the antinociceptive effect using distinct animal models (hot plate test, formalin-induced nociception and complete Freud's adjuvant induced paw inflammation). The DIM-loaded NCs (composed by primula oil and ethylcellulose) were characterized using differential scanning calorimetry, thermogravimetric analysis, Fourier-transformed infrared spectroscopy, X-ray diffractometry and scanning electron microscopy. The physicochemical characterization demonstrated that DIM could be molecularly dispersed into the NCs, whose size was nanometric with a spherical shape.
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