Publications by authors named "Taina S Kaiponen"
BRCA1 and BRCA2 both function in DNA double-strand break repair by homologous recombination (HR). Due to their HR defect, BRCA1/2-deficient cancers are sensitive to poly(ADP-ribose) polymerase inhibitors (PARPis), but they eventually acquire resistance. Preclinical studies yielded several PARPi resistance mechanisms that do not involve BRCA1/2 reactivation, but their relevance in the clinic remains elusive.
View Article and Find Full Text PDFUniventricular heart malformations are rarely described in the veterinary literature. This case report describes a single-inlet univentricular heart with persistent truncus arteriosus as a cause of death of a captive-bred, 2-day-old, female Sumatran orangutan (Pongo abelii), a critically endangered species.
View Article and Find Full Text PDFArticle Synopsis
- - A 7-month-old cat showed stunted growth, recurrent low blood sugar, and altered behavior, leading to the diagnosis of hyposomatotropism, an unusual growth hormone deficiency.
- - MRI revealed a pituitary cyst and underdevelopment of the pituitary gland, and later evaluations indicated hormone deficiencies affecting the cat's reproductive system.
- - The cat ultimately developed dilated cardiomyopathy, leading to heart failure and death, marking the first documented case linking DCM and hyposomatotropism in cats, similar to findings in humans.
Background: This report describes a case of solitary tracheal lymphoma in a 14-year-old alpaca mare.
Case Presentation: The alpaca was referred for dyspnea and inspiratory noise. The clinical examination included complete blood cell count, blood chemistry, endoscopy, ultrasound, radiographs, and computed tomography (CT).