Analysis of metabolites associated with ADIPOQ genotypes in individuals with type 2 diabetes mellitus.

Diabetes mellitus (DM) is a significant public health problem and it is known that the identification of molecular markers involved in glycemic control can impact disease control. Although the rs266729 polymorphism located in the promoter of the adiponectin gene (ADP) has been shown to be a candidate for involvement in glycemic control, the genotypic groups have never been characterized in terms of metabolomic aspects. Objective: Analyze the metabolites present in the rs266729 genotype groups.

MiR-9-3 hypermethylation is associated with stages of diabetic retinopathy.

Purpose: To investigate the potential relation between methylation of miR-9-3 and stages of diabetic retinopathy (DR). Additionally, we explored whether miR-9-3 methylation impacts the serum levels of Vascular Endothelial Growth Factor (VEGF).

Methods: A cross-sectional study was conducted with 170 participants with type 2 diabetes, including a control group ( = 64) and a diabetes retinopathy group ( = 106), which was further divided into NPDR ( = 58) and PDR ( = 48) subgroups.

Metabolomic analysis of retinopathy stages and amputation in type 2 diabetes.

Background: Diabetic retinopathy (DR) and limb amputation are frequent complications of diabetes that cannot always be explained by blood glucose control. Metabolomics is a science that is currently being explored in the search for biomarkers or profiles that identify clinical conditions of interest.

Objective: This study aimed to analyze, using a metabolomic approach, peripheral blood samples from type 2 diabetes mellitus (DM2) individuals, compared with those with diabetic retinopathy and limb amputation.

MTHFR Polymorphisms and Cardiac Parameters in Patients with Diabetic Retinopathy.

Background: Diabetes Mellitus (DM) is directly associated with cardiovascular dysfunctions and microvascular complications, such as diabetic retinopathy (DR). The association between DR and increased risks of developing cardiovascular diseases has been described. The low activity of the Methylenetetrahydrofolate reductase (MTHFR), an enzyme involved in the metabolism of homocysteine, can lead to hyperhomocysteinemia that has already been related to cardiac outcomes and resistance to insulin.

Metabolic impact of the VDR rs1544410 in diabetic retinopathy.

Aims: To investigate the association between BsmI and DM2 in patients with and without DR and to correlate with clinical parameters in a population in northeastern Brazil.

Methods: Cross-sectional case-control study in which data were collected from 285 individuals, including 128 patients with DM2 and 157 with DR. Clinical, biochemical and anthropometric parameters were analyzed, in addition to the single nucleotide polymorphism (SNP) BsmI of the VDR gene (rs1544410), genotyped by PCR-RFLP.

Physical Activity Level Influences Gene Methylation Profile in Diabetic Patients.

Introduction: methylation status is associated with microvascular complications in diabetes, but the factors influencing this profile remain unknown.

Objective: The aim of this study was to evaluate the influence of physical activity level and nutritional status on the methylation profile of the gene in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 111 patients, 43 men and 68 women diagnosed with DM (7.