Clinical characteristics and long-term health in celiac disease patients diagnosed in early childhood: Large cohort study.

Background: Early detection of celiac disease could theoretically prevent most of the disease-associated complications, but long-term effects of this approach are unclear.

Aims: To investigate features at diagnosis and adulthood health in celiac disease patients diagnosed in early childhood in 1965-2014.

Methods: Medical data on 978 pediatric patients were collected and study questionnaires sent to 559 adult patients who were diagnosed in childhood.

Nonbiopsy Approach for Celiac Disease Is Accurate When Using Exact Duodenal Histomorphometry: Prospective Study in 2 Countries.

Goals: To test the accuracy of serology-based criteria for diagnosing celiac disease utilizing quantitative histomorphometry.

Background: The revised European pediatric guidelines allow noninvasive celiac disease diagnosis for a subgroup of children. However, in some of the studies on this issue, the positive predictive value (PPV) of serology has remained suboptimal, possibly because of challenges of histopathology as the reference standard.

Long-term health and treatment outcomes in adult coeliac disease patients diagnosed by screening in childhood.

Background: The diagnostic yield of coeliac disease could be improved by screening in at-risk groups, but long-term benefits of this approach are obscure.

Objective: To investigate health, quality of life and dietary adherence in adult coeliac patients diagnosed in childhood by screening.

Methods: After thorough evaluation of medical history, follow-up questionnaires were sent to 559 adults with a childhood coeliac disease diagnosis.

Secular trends in poisonings leading to hospital admission among Finnish children and adolescents between 1971 and 2005.

Objective: To investigate the secular trends in childhood poisonings leading to hospitalization in Finland.

Study Design: All children and adolescents age 0 to 19 years hospitalized in Finland with the primary diagnosis of poisoning between 1971 and 2005 were identified using the International Classification of Diseases.

Results: During the study period, there were 41 862 hospitalizations with 96 427 hospital bed days for poisoning in 38 582 children and adolescents.

Paediatric poisonings treated in one Finnish main university hospital between 2002 and 2006.

Aim: Acute poisonings are a major cause of morbidity among children. This study aims to describe the incidence and nature of emergency visits for acute paediatric poisoning among Finnish children.

Methods: All patients younger than 16 years admitted to the Tampere University Hospital's emergency department with a diagnosis of poisoning during 2002-2006 were identified from the Hospital Information System using the International Classification of Diseases (ICD-10).

Rectal bleeding in infancy: clinical, allergological, and microbiological examination.

Objective: Rectal bleeding is an alarming symptom and requires additional investigation. In infants it has been explained mainly by hypersensitivity. In addition to dietary antigens, intraluminal microbial agents challenge the immature gut mucosa.

Characterization of breast milk received by infants with gross blood in stools.

Objective: The aim of this study was to ascertain factors that might be protective of the appearance of gross blood in the stools of breast-fed infants.

Methods: Logistic regression models were formed to search for variables possibly explaining the condition. In addition to the analyzed breast milk factors, mother's allergic disease was introduced into the models to control for its possible confounding effect.

Microbiota composition of the intestinal mucosa: association with fecal microbiota?

The fecal and mucosal microbiota of infants with rectal bleeding and the fecal microbiota of healthy age-matched controls were investigated by fluorescent in situ hybridization. Bifidobacteria were the main genus in both the feces and mucosa. The other genera tested, Bacteroides, Clostridium, Escherichia coli and lactobacilli/enterococci, represented only minor constituents.

Weaning to hypoallergenic formula improves gut barrier function in breast-fed infants with atopic eczema.

Objectives: Infants may be sensitized to dietary antigens even during exclusive breast-feeding. Because food antigen traces in breast milk may have harmful effects on gut barrier function in infants with atopy, the authors sought to evaluate whether or not it is beneficial to shift such infants from breast milk to a hypoallergenic formula.

Methods: Fifty-six infants (mean age, 5.

Breast milk fatty acids, eicosanoids, and cytokines in mothers with and without allergic disease.

Allergic disease (AD), including atopic eczema, asthma, allergic rhinitis, and food allergy, is characterized by an imbalance between cytokines produced by distinct T-helper cell subtypes. Whether this imbalance can be transferred from mother to breast milk remains to be established. The objective was to investigate the concentrations and interactions of nutritional and inflammatory factors in breast milk.