Publications by authors named "Taiko Seno"
Article Synopsis
- The study investigates the use of a modified coil planet centrifuge method to detect and measure mixed cell populations using monoclonal antibodies (MoAbs) instead of traditional polyclonal antisera, due to the latter's declining availability.
- The method was tested on packed red blood cells (RBCs) from different ABO blood types, chimeras, and patients who underwent ABO-incompatible hematopoietic progenitor cell transplantation (HPCT), revealing the ability to detect ABO chimerism as low as 0.1 percent.
- The findings confirm that the new method can analyze ABO chimerism and differentiate ABO variants with similar accuracy to existing methods, potentially improving early detection of relapse or rejection in HPCT patients.
Background: The Rh system is the most polymorphic of the blood group systems and is of major importance in transfusion medicine. The partial D phenotypes lack one or more of the D epitopes. These variants appear to have arisen through hybrid RhD-CE-D or by spontaneous point mutations in RhD.
View Article and Find Full Text PDF