Publications by authors named "Taiki Shima"
Article Synopsis
- Adenovirus is a significant cause of febrile illness and can lead to serious conditions like encephalitis/encephalopathy in children, prompting a study on its clinical features in Japan.
- A nationwide survey collected data on children diagnosed with adenovirus-associated encephalitis/encephalopathy (AdVE) from January 2014 to March 2019, revealing demographic and clinical details, including outcomes.
- The findings indicated that previous febrile seizures were common, with a mixed prognosis; a subset of patients had poor outcomes associated with certain laboratory markers, and different encephalopathy subtypes existed among affected children.
For the efficient diagnosis of rare and undiagnosed diseases, the parallel detection of copy number variants (CNVs) and single nucleotide variants using exome analysis is required. Recently, our group reported the usefulness of a program called EXCAVATOR2, which screens for CNVs from aligned exome data in bam format. This method is expected to contribute to the identification of structural variants and to improve the diagnosis rate, especially for the diagnosis of autosomal recessive disease, when a conventional exome analysis identifies a pathogenic variant in one allele but not the other.
View Article and Find Full Text PDFSepsis and septic shock are associated with high mortality and neurodevelopmental impairment in preterm infants. Recently, endotoxin and mediator removal using a polymyxin B-immobilized fiber column for direct hemoperfusion (PMX-DHP) has been used for the management of septic shock even in neonates. Although early withdrawal from shock with PMX-DHP contributes to survival, its effect on neurodevelopment after discharge is unclear.
View Article and Find Full Text PDFArticle Synopsis
- Norovirus, a significant cause of gastroenteritis, can also lead to encephalitis/encephalopathy in children, prompting a national survey in Japan to investigate its clinical features.
- The survey gathered data from pediatricians and hospitals on 29 children diagnosed with norovirus-associated encephalitis/encephalopathy, revealing a median age of 2 years and 8 months, with 15 of them experiencing poor outcomes.
- Key findings indicate that quicker onset of neurological symptoms, high serum creatinine, and abnormal blood glucose levels are linked to worse outcomes, highlighting a need for further research to identify effective treatments.
Article Synopsis
- The study aimed to assess the safety and effectiveness of fosphenytoin (fPHT) for treating seizures in children diagnosed with acute encephalopathy.
- Researchers gathered data from 38 children who received fPHT, noting a 71% efficacy rate in stopping seizures across various types of encephalopathy.
- Limited adverse effects were reported, indicating that fPHT is both effective and well-tolerated in this patient population.
Purpose: We assessed lateralization of interictal epileptiform discharges (IEDs) in children with intractable epilepsy secondary to tuberous sclerosis complexes (TSCs) during rapid eye movement sleep (R), compared with non-rapid eye movement sleep (NR) and wakefulness (W), to determine epileptogenicity of R-IEDs.
Methods: We retrospectively studied 23 children with TSC, who underwent prolonged scalp video-electroencephalography (EEG) and magnetic resonance imaging (MRI). We determined the lateralization of ictal EEG, clinical semiology, and the largest tuber on MRI.